复方鱼腥草合剂联合头孢克肟胶囊治疗急性咽炎风热证临床研究  

Clinical Study of Compound Yuxingcao Mixture Combined with Cefixime Capsules for Acute Pharyngitis with Wind-Heat Syndrome

作　　者：李莉[1] 吴振波[1] LI Li;WU Zhenbo

机构地区：[1]丽水市中心医院药学部,浙江丽水323000

出　　处：《新中医》2023年第6期102-105,共4页New Chinese Medicine

摘　　要：目的:观察复方鱼腥草合剂联合头孢克肟胶囊治疗急性咽炎风热证的临床疗效。方法:选取88例急性咽炎风热证患者,采用随机数字表法分为对照组和观察组各44例。对照组给予头孢克肟胶囊治疗,观察组在对照组基础上给予复方鱼腥草合剂治疗,2组均治疗5 d。比较2组临床疗效、症状消失时间、不良反应发生率,以及治疗前后中医证候评分、血清炎症指标水平。结果:治疗5 d后,观察组临床疗效总有效率95.45%,高于对照组81.82%(P<0.05)。2组咽痛、咽部干燥灼热、吞咽不利、发热、恶寒、口渴评分均较治疗前降低(P<0.05),观察组上述6项中医证候评分均低于对照组(P<0.05)。观察组咽痛、咽部黏膜红肿、咽部灼热消失时间均短于对照组(P<0.05)。2组血清白细胞介素-6 (IL-6)、C-反应蛋白(CRP)、白细胞介素-1β (IL-1β)、肿瘤坏死因子-α (TNF-α)水平均较治疗前降低(P<0.05),观察组上述4项血清炎症指标水平均低于对照组(P<0.05)。治疗期间,观察组不良反应发生率11.36%,与对照组6.82%比较,差异无统计学意义(P>0.05)。结论:复方鱼腥草合剂联合头孢克肟胶囊治疗急性咽炎风热证可提高临床疗效,改善患者的临床症状,抑制炎症反应,安全可靠。Objective: To observe the clinical effect of Compound Yuxingcao Mixture combined with Cefixime Capsules for acute pharyngitis with wind-heat syndrome. Methods: A total of 88 cases of patients with acute pharyngitis with wind-heat syndrome were selected and divided into the control group and the observation group according to the random number table method,with 44 cases in each group. The control group was treated with Cefixime Capsules,and the observation group was additionally treated with Compound Yuxingcao Mixture based on the treatment of the control group. Both groups were treated for5 days. Traditional Chinese medicine(TCM) syndrome scores and the levels of inflammatory indexes in serum before and after treatment, clinical effects, the disappearance time of symptoms, and the incidence of adverse reactions were compared between the two groups. Results:After a 5-day treatment,the total effective rate of clinical effects was 95.45% in the observation group,higher than that of 81.82%in the control group(P<0.05). The scores of pharyngeal pain, dryness and burning sensation in the pharynx, dysphagia, fever, aversion to cold, and thirst in the two groups were decreased when compared with those before treatment(P<0.05), and the above 6 TCM syndrome scores in the observation group were lower than those in the control group(P<0.05). The disappearance time of pharyngeal pain, redness and swelling of pharynx mucosa, and burning sensation in the pharynx in the observation group were shorter than those in the control group(P<0.05). The levels of interleukin-6(IL-6),C-reactive protein(CRP),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α) in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of the above 4 inflammatory indexes in serum in the observation group were lower than those in the control group(P<0.05). During treatment, the incidence of adverse reactions was 11.36% in the observation group, and 6.82% in the control group, there being no significance

关 键 词：急性咽炎 风热证 复方鱼腥草合剂 头孢克肟胶囊 中医证候 炎症指标 

分 类 号：R766.14[医药卫生—耳鼻咽喉科]