血清IL-6、RANTES与儿童难治性肺炎支原体肺炎的关系  

Expression of serum IL-6 and RANTES in children with refractory pneumonia caused by mycoplasma pneumoniae and their relationship with prognosis

作　　者：张松林[1] 熊蕾蕾[1] 余燕娟 郭燕军 ZHANG Songlin;XIONG Leilei;YU Yanjuan;GUO Yanjun(Department of Respiratory,Children's Hospital Affiliated of Zhengzhou University,Henan Provincial Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院呼吸内科,河南郑州450000

出　　处：《中华全科医学》2023年第4期619-621,684,共4页Chinese Journal of General Practice

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190919)。

摘　　要：目的 探讨难治性肺炎支原体肺炎(RMPP)的影响因素,分析血清白介素6(IL-6)、受激活调节正常T细胞表达和分泌因子(RANTES)对RMPP的诊断价值。方法 选取2019年3月—2021年4月收治于郑州大学附属儿童医院的70例肺炎支原体肺炎(MPP)患儿,根据诊断标准分为MPP组(34例)和RMPP组(36例)。对RMPP产生的危险因素进行单因素分析,差异有统计学意义的指标进一步行多因素logistic回归分析,并绘制ROC曲线分析血清IL-6、RANTES对RMPP的诊断价值。结果 RMPP患儿发热持续时间>10 d占比及血清IL-6、RANTES水平高于MPP组,差异有统计学意义(均P<0.05)。多因素logistic回归分析显示,血清IL-6(OR=2.451,95%CI:1.856~3.046)、RANTES(OR=2.678,95%CI:1.953~3.403)为RMPP发生的影响因素。ROC曲线分析结果显示,血清IL-6、RANTES及两者联合预测RMPP发生的AUC分别为0.686、0.701、0.824。结论 血清IL-6、RANTES水平较高是RMPP发生的危险因素,两者联合检测用于诊断RMPP具有较高的临床价值。Objective To explore the influencing factors of refractory mycoplasma pneumoniae pneumonia(RMPP),and analyze the diagnostic value of serum interleukin-6(IL-6),activated normal T cell expression and secretion factors(RANTES)in RMPP.Methods A total of 70 children with mycoplasma pneumoniae pneumonia(MPP)admitted to the Affiliated Children's Hospital of Zhengzhou University from March 2019 to April 2021 were selected and divided into MPP group(34 cases)and RMPP group(36 cases)according to diagnostic criteria.The risk factors of RMPP were analysed by univariate analysis,and differences were analysed by multivariate logistic regression.In addition,the receiver operating characteristic curve(ROC)was drawn to analyse the diagnostic value of serum IL-6 and RANTES for RMPP.Results The proportion of fever duration>10 days and serum IL-6,RANTES levels in children with RMPP were higher than those in the MPP group,and the differences were statistically significant(all P<0.05).Multivariate logistic regression analysis showed that serum IL-6(OR=2.451,95%CI:1.856-3.046)and RANTES(OR=2.678,95%CI:1.953-3.403)were the risk factors for the occurrence of RMPP.ROC showed that serum IL-6,the AUCs of RANTES and their combination in evaluating the prognosis of RMPP patients were 0.686,0.701 and 0.824,respectively.Conclusion Higher levels of serum IL-6 and RANTES are the risk factors for the occurrence of RMPP,and their combined detection has high clinical value in the diagnosis of RMPP.

关 键 词：难治性肺炎支原体肺炎 白介素6 受激活调节正常T细胞表达和分泌因子 预后 

分 类 号：R725.6[医药卫生—儿科] R563.15[医药卫生—临床医学]