2型糖尿病合并冠心病患者血浆半乳糖凝集素3水平及相关因素研究  

Plasma galectin-3 level and related factors in type 2 diabetic patients with coronary artery disease

作　　者：田梅梅[1] 李敏 刘岩[1] 徐静 李玉坤[1] 支忠继[1] TIAN Mei-mei;LI Min;LIU Yan;XU Jing;LI Yu-kun;ZHI Zhong-ji(The Second Department of Endocrinology,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院内分泌二科,河北石家庄050051

出　　处：《河北医科大学学报》2023年第4期402-406,共5页Journal of Hebei Medical University

基　　金：河北省医学科学研究课题计划(20170642)。

摘　　要：目的 探讨血浆半乳糖凝集素3(galectin-3,Gal-3)水平与2型糖尿病(type 2 diabetes mellitus,T2DM)合并冠心病(coronary artery disease,CAD)的相关性。方法 选取T2DM患者60例设为T2DM组,T2DM合并CAD患者60例设为T2DM+CAD组。收集患者病程、年龄等数据。酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)法检测两组血浆Gal-3水平,同时明确血浆Gal-3水平与心脏射血分数、糖化血红蛋白、C反应蛋白等指标的相关性。结果 T2DM与T2DM+CAD组患者年龄、性别、吸烟情况、饮酒情况以及血脂等生化指标差异无统计学意义。与T2DM组相比,T2DM+CAD组患者血浆Gal-3明显升高(P<0.01),且血浆Gal-3水平与高密度脂蛋白水平呈负相关(P<0.05)。多元线性回归分析显示糖化血红蛋白、C反应蛋白是血浆Gal-3的影响因素。Logistic回归分析显示血浆Gal-3水平、年龄是CAD发生的影响因素。结论 T2DM+CAD患者血浆Gal-3水平明显升高,可能是T2DM患者发生CAD的影响因素。Objective To investigate the correlation between plasma galectin-3(Gal-3)level and type 2 diabees mellitus(T2DM)complicated with coronary artery disease(CAD).Methods Sixty patients with T2DM(T2DM group)and 60 patients with T2DM and CAD(T2DM+CAD group)were enrolled in this study.Patients'data including course of disease and age were collected.Left ventricular ejection fraction was assessed by echocardiography.Enzyme-linked immunosorbent assay(ELISA)was used to measure plasma Gal-3 levels in the two groups.The correlation of Gal-3 levels with cardiac ejection fraction,glycosylated hemoglobin and C-reactive protein(CRP)was analyzed.Results There was no significant difference in age,gender,smoking,alcohol consumption,and biochemical indicators such as blood lipids between the T2DM and T2DM+CAD groups.Compared with that in T2DM patients,plasma Gal-3 level was significantly increased in patients with T2DM+CAD(P<0.01).Plasma Gal-3 level was negatively correlated with high-density lipoprotein(HDL)level(P<0.05).Multiple linear regression analysis showed that glycosylated hemoglobin and CRP were influencing factors for plasma Gal-3 levels.Logistic regression analysis showed that plasma Gal-3 level and age were the risk factors influencing the occurrence of CAD in T2DM patients.Conclusion Plasma Gal-3 level is significantly increased in T2DM+CAD patients,which may be an influencing factor for the occurrence of CAD in T2DM patients.

关 键 词：糖尿病 2型 冠心病 半乳糖凝集素3 

分 类 号：R587.1[医药卫生—内分泌]