IgE、IL-1β、TGF-β1、VCAM-1在过敏性鼻炎中的表达及与病情严重程度的相关性  

Expression of IgE,IL-1β,TGF-β1 and VCAM-1 in allergic rhinitis and their correlation with the severity of the disease

作　　者：尚建华 韩琳[2] 孙景元[3] 孙守军[3] 温雪菲 SHANG Jian-hua;HAN Lin;SUN Jing-yuan;SUN Shou-jun;WEN Xue-fei(Department of Otorhinolaryngology,Hebei Yiling Hospital,Hebei Province,Shijiazhuang 050000,China;Department of Otorhinolaryngology,Shijiazhuang Hospital of Traditional Chinese Medicine,Hebei Province,Shijiazhuang 050000,China;Department of Otorhinolaryngology,Baoding Children′s Hospital,Hebei Province,Baoding 071000,China)

机构地区：[1]河北以岭医院耳鼻咽喉科,河北石家庄050000 [2]河北省石家庄市中医院耳鼻喉科,河北石家庄050000 [3]河北省保定市儿童医院耳鼻喉科,河北保定071000

出　　处：《河北医科大学学报》2023年第4期459-464,共6页Journal of Hebei Medical University

基　　金：保定市科技计划项目(2141ZF112)。

摘　　要：目的 探讨免疫球蛋白E(immunoglobulin E,IgE)、白细胞介素1β(interleukin-1β,IL-1β)、转化生长因子β1(transforming growth factor-β1,TGF-β1)、血管细胞黏附分子1(vascular cell adhesion molecule-1,VCAM-1)在过敏性鼻炎(allergic rhinitis,AR)中的表达及与病情严重程度的相关性。方法 选取河北省保定市儿童医院收治的AR患者167例为AR组,根据病情严重程度分为轻度组61例和中重度组106例,依据过敏原类型分为花粉组、霉菌组、尘螨组,另选取同期健康体检自愿者63例为对照组。采用酶联免疫吸附法检测血清IgE、IL-1β、TGF-β1、VCAM-1水平,Logistic回归分析基线资料、血清IgE、IL-1β、TGF-β1、VCAM-1水平与AR病情严重程度的关系。结果 AR组血清IgE、IL-1β、TGF-β1、VCAM-1水平高于对照组(P<0.05)。花粉组血清IgE、IL-1β、TGF-β1、VCAM-1水平高于霉菌组、尘螨组(P<0.05)。中重度组血清IgE、IL-1β、TGF-β1、VCAM-1水平高于轻度组(P<0.05)。中重度组花粉过敏原比例高于轻度组(P<0.05),Logistic回归分析显示,血清IgE(OR=1.011,95%CI:1.006~1.017)、IL-1β(OR=1.035,95%CI:1.002~1.069)、TGF-β1(OR=1.010,95%CI:1.006~1.015)、VCAM-1(OR=1.654,95%CI:1.267~2.159)水平与花粉过敏原(OR=1.322,95%CI:1.021~1.899)为AR中-重度的危险因素(P<0.05)。结论 IgE、IL-1β、TGF-β1、VCAM-1在AR患者血清中高表达,IgE、IL-1β、TGF-β1、VCAM-1、花粉过敏原均与病情严重程度密切相关。Objective To investigate the expression of immunoglobulin E(IgE),interleukin-1β(IL-1β),transforming growth factor-β1(TGF-β1)and vascular cell adhesion molecule-1(VCAM-1)in allergic rhinitis(AR)and their correlation with the severity of the disease.Methods A total of 167 AR patients admitted to Baoding Children′s Hospital of Hebei Province were selected as the AR group.According to the severity of the disease,they were divided into mild group(n=61)and moderate to severe group(n=106).According to the type of allergen,they were divided into pollen group,mold group and dust mite group.In addition,63 healthy volunteers undergoing physical examination during the same period were selected as the control group.The levels of serum IgE and IL-1β,TGF-β1 and VCAM-1 level were detected by enzyme-linked immunosorbent assay(ELISA).The relationship between baseline data,the levels of serum IgE,IL-1β,TGF-β1 and VCAM-1 and severity of AR was analyzed bylogistic regression analysis.Results The levels of serum IgE,IL-1β,TGF-β1 and VCAM-1 were higher in AR group than in control group(P<0.05),higher in pollen group than in mold and dust mite groups(P<0.05),and higher in moderate to severe group than in mild group(P<0.05).The proportion of pollen allergens in moderate to severe group was higher than that in mild group(P<0.05).Logistic regression analysis showed that serum IgE(OR=1.011,95%CI:1.006-1.017),IL-1β(OR=1.035,95%CI:1.002-1.069),TGF-β1(OR=1.010,95%CI:1.006-1.015),VCAM-1(OR=1.654,95%CI:1.267-2.159)and pollen allergen(OR=1.322,95%CI:1.021-1.899)were risk factors for moderate to severe AR(P<0.05).Conclusion IgE,IL-1β,TGF-β1 and VCAM-1 are highly expressed in the serum of AR patients.IgE,IL-1β,TGF-β1,VCAM-1 and pollen allergen are closely related to the severity of the disease.

关 键 词：鼻炎 变应性 季节性 免疫球蛋白E 白细胞介素-1Β 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]