血液灌流治疗多器官功能障碍综合征的效果观察  

Effect Observation of Hemoperfusion in Treatment of Multiple Organ Dysfunction Syndrome

作　　者：李丽华[1] Li Li-hua(Guizhou Aerospace Hospital,Zunyi 563000,Guizhou Province,China)

机构地区：[1]贵州航天医院,贵州遵义563000

出　　处：《中国社区医师》2023年第8期61-63,共3页Chinese Community Doctors

摘　　要：目的:探讨血液灌流治疗多器官功能障碍综合征(MODS)的效果。方法:选取2022年3月—2023年1月贵州航天医院收治的66例MODS患者作为研究对象,根据随机数字表法分为试验组与对照组,各33例。对照组给予血液透析治疗,试验组在对照组基础上给予血液灌流治疗,比较两组治疗成功率、心肺功能参数、生化指标、炎性因子、肝功能指标。结果:试验组治疗成功率高于对照组,差异有统计学意义(P=0.001)。治疗前,两组心率(HR)、平均动脉压(MAP)、中心静脉压(CVP)比较,差异无统计学意义(P>0.05);治疗后,试验组HR、MAP、CVP低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血尿素氮(BUN)、肌酐(Cr)、总胆红素(TBIL)水平比较,差异无统计学意义(P>0.05);治疗后,试验组BUN、Cr、TBIL水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组C反应蛋白(CRP)、白细胞介素-6(IL-6)水平比较,差异无统计学意义(P>0.05);治疗后,试验组CRP、IL-6水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)水平比较,差异无统计学意义(P>0.05);治疗后,试验组DBIL水平低于对照组,ALT水平高于对照组,差异有统计学意义(P<0.05)。结论:血液灌流治疗可降低患者炎性因子水平,改善生化指标和肝功能指标,提高治疗成功率。Objective:To investigate the effect of hemoperfusion in the treatment of multiple organ dysfunction syndrome(MODS).Methods:A total of 66 patients with MODS admitted to Guizhou Aerospace Hospital from March 2022 to January 2023 were selected as the study subjects.They were divided into trial group and control group according to random number table method,with 33 cases in each group.The control group was given hemodialysis treatment,while the trial group was given hemoperfusion treatment on the basis of the control group.The treatment success rate,cardiopulmonary function parameters,biochemical indicators,inflammatory factors,and liver function indicators were compared between the two groups.Results:The treatment success rate in the trial group was higher than that in the control group,with a statistically significant difference(P=0.001).Before treatment,there was no statistically significant difference in heart rate(HR),mean arterial pressure(MAP),and central venous pressure(CVP)between the two groups(P>0.05).After treatment,HR,MAP,and CVP in the trial group were lower than those in the control group,with statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in the levels of blood urea nitrogen(BUN),creatinine(Cr),and total bilirubin(TBIL)between the two groups(P>0.05).After treatment,the levels of BUN,Cr,and TBIL in the trial group were lower than those in the control group,with statistically significant difference(P<0.05).Before treatment,there was no significant difference in the levels of C-reactive protein(CRP)and interleukin-6(IL-6)between the two groups(P>0.05).After treatment,the CRP and IL-6 levels in the trial group were lower than those in the control group,with statistically significant difference(P<0.05).Before treatment,there was no significant difference in the levels of direct bilirubin(DBIL)and alanine aminotransferase(ALT)between the two groups(P>0.05).After treatment,the DBIL level in the trial group was lower than that in the control gro

关 键 词：血液灌流 多器官功能障碍综合征 炎性因子 肝功能 

分 类 号：R459.7[医药卫生—急诊医学]