高压氧治疗颅脑损伤致迁延性昏迷疗效分析  

Analysis of the Therapeutic Effect of Hyperbaric Oxygen Therapy in the Treatment of Craniocerebral Injury⁃induced Persistent Coma

作　　者：郭琳琳 刘永芳[1] 陈思梦 GUO Linlin;LIU Yongfang;CHEN Simeng(Department of Hyperbaric Oxygen,The 7th People’s Hospital of Zhengzhou,Zhengzhou,Henan 450016,China)

机构地区：[1]郑州市第七人民医院高压氧科,河南郑州450016

出　　处：《中国烧伤创疡杂志》2023年第2期122-125,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的分析高压氧治疗颅脑损伤致迁延性昏迷的临床效果。方法选取2018年8月至2020年8月郑州市第七人民医院收治的60例颅脑损伤导致的迁延性昏迷患者作为研究对象,根据不同治疗方式将其分为观察组(30例)与对照组(30例),观察组患者在常规治疗的基础上联合应用高压氧,对照组患者单纯予以常规治疗,对比观察两组患者格拉斯哥昏迷评分(GCS)、格拉斯哥预后评分(GOS)、美国国立卫生研究院卒中量表(NIHSS)评分及脑血流动力学指标变化情况结果治疗1个月后,观察组患者GCS、GOS均明显高于对照组(t=6.655、2.948,P<0.001、P=0.005);治疗1、3、6个月后,观察组患者NIHSS评分均明显低于对照组(t=5.742、7.861、12.339,P均<0.001);治疗1个月后,观察组患者颈总动脉收缩期峰值血流速度(Vs)、平均血流速度(Vm)均明显大于对照组(t=3.961、6.041,P均<0.001)。结论高压氧可明显改善颅脑损伤导致的迁延性昏迷患者脑血流动力学状态,促进神经功能恢复,缓解患者意识障碍及昏迷等症状,临床应用价值较高。Objective To analyze the clinical efficacy of hyperbaric oxygen therapy in the treatment of craniocerebral injury⁃induced persistent coma.Methods Sixty patients with craniocerebral injury⁃induced persistent coma,admitted to The 7th People’s Hospital of Zhengzhou from August 2018 to August 2020,were enrolled as research subjects,and divided into observation group(n=30),receiving routine treatment plus hyperbaric oxygen,and control group(n=30),receiving routine treatment alone.The Glasgow coma scale(GCS),Glasgow outcome scale(GOS),National Institutes of Health Stroke Scale(NIHSS)score,and changes of cerebral hemodynamic parameters were compared between the two groups.Results After one month of treatment,the GCS and GOS of patients in the observation group were significantly higher than that in the control group(t=6.655 and 2.948,P<0.001,P=0.005);After 1,3,and 6 months of treatment,the NIHSS scores of patients in the observation group were all significantly lower compared with the control group(t=5.742,7.861 and 12.339,all P<0.001).After one month of treatment,the peak systolic blood flow velocity(Vs)and mean blood flow velocity(Vm)of common carotid artery of patients in the observation group were significantly higher than that in the control group(t=3.961 and 6.041,both P<0.001).Conclusion Hyperbaric oxygen therapy can significantly improve the cerebral hemodynamic status of patients with craniocerebral injury⁃induced persistent coma,promote the recovery of neurological functions,alleviate symptoms such as consciousness disorders and coma,and has a much high value of clinical application.

关 键 词：颅脑损伤 迁延性昏迷 高压氧 格拉斯哥昏迷评分 格拉斯哥预后评分 脑血流动力学 

分 类 号：R651.15[医药卫生—外科学]