CCAAT/Enhancer-Binding Proteins in Fibrosis:Complex Roles Beyond Conventional Understanding  

作　　者：Lexun Wang Jiaojiao Feng Yanyue Deng Qianqian Yang Quxing Wei Dewei Ye Xianglu Rong Jiao Guo 

机构地区：[1]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine,China [2]Key Laboratory of Glucolipid Metabolic Disorder,Ministry of Education of China,China [3]Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine,China [4]Institute of Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou,China

出　　处：《Research》2023年第1期231-272,共42页研究（英文）

基　　金：supported by the Major basic and applied basic research projects of Guangdong Province of China(2019B030302005);the Natural Science Foundation of China(81830113);the National Key Research and Development Program of China(2018YFC1704200);the Basic and applied basic research project of Guangdong Province of China(2020A1515010155);the“Innovation and Strengthening University Project”Subsidized Project of Guangdong Pharmaceutical University(2018KTSCX112).

摘　　要：CCAAT/enhancer-binding proteins(C/EBPs)are a family of at least six identified transcription factors that contain a highly conserved basic leucine zipper domain and interact selectively with duplex DNA to regulate target gene expression.C/EBPs play important roles in various physiological processes,and their abnormal function can lead to various diseases.Recently,accumulating evidence has demonstrated that aberrant C/EBP expression or activity is closely associated with the onset and progression of fibrosis in several organs and tissues.During fibrosis,various C/EBPs can exert distinct functions in the same organ,while the same C/EBP can exert distinct functions in different organs.Modulating C/EBP expression or activity could regulate various molecular processes to alleviate fibrosis in multiple organs;therefore,novel C/EBPs-based therapeutic methods for treating fibrosis have attracted considerable attention.In this review,we will explore the features of C/EBPs and their critical functions in fibrosis in order to highlight new avenues for the development of novel therapies targeting C/EBPs.

关 键 词：ORGANS expression COMPLEX 

分 类 号：R5[医药卫生—内科学]