布地奈德雾化联合氨溴索治疗小儿支气管肺炎疗效及对血清CRP PCT水平的影响  

Curative Effect of Budesonide Nebulization Combined with Ambroxol in the Treatment of Pediatric Bronchopneumonia and Its Effect on Serum CRP and PCT Levels

作　　者：刘乐 王君霞 甘新茹 曾晓洁 LIU Le;WANG Junxia;GAN Xinru(General Hospital of Western Theater,Sichuan Chengdu 610000,China)

机构地区：[1]西部战区总医院儿科,四川成都610000

出　　处：《河北医学》2023年第4期681-685,共5页Hebei Medicine

基　　金：四川省卫生健康科研课题,(编号:19PJ286)。

摘　　要：目的:探究布地奈德雾化联合氨溴索治疗小儿支气管肺炎疗效及对血清C反应蛋白(CRP)、降钙素原(PCT)水平的影响。方法:选择2020年6月至2021年9月来我院就诊的支气管肺炎患儿186例,按照随机数表法,分成观察组(n=93)和对照组(n=93)。对照组采用布地奈德雾化治疗,观察组在此基础上联合氨溴索静滴治疗。比较两组治疗后临床疗效,比较两组治疗前、后的炎症因子(CRP、PCT)水平及免疫功能(IgG、IgM、IgA)水平。结果:治疗后,观察组的总有效率为93.55%,高于对照组的71.72%(P<0.05);治疗后,观察组的临床症状消失时间均短于对照组(P<0.05);两组治疗5d后的CRP、PCT水平均低于治疗前,同时观察组治疗前、后CRP、PCT的差值分别为(25.93±4.54)mg/L、(1.03±0.25)μg/L,均高于对照组的(16.15±3.72)mg/L、(0.84±0.19)μg/L(P<0.05);两组治疗5d后的IgA、IgM、IgG水平均高于治疗前,同时观察组治疗前、后IgA、IgM、IgG的差值分别为(4.15±0.87)g/L、(0.46±0.13)g/L、(0.63±0.22)g/L,均高于对照组的(1.67±0.39)g/L、(0.27±0.06)g/L、(0.27±0.08)g/L(P<0.05);观察组发生不良反应合计9例(9.68%),对照组发生不良反应合计7例(7.53%),两组比较差异无统计学意义(P>0.05)。结论:布地奈德雾化联合氨溴索治疗小儿支气管肺炎疗效优于单一布地奈德雾化,对患儿临床症状、炎症因子、免疫功能的改善效果优于单一布地奈德雾化,且具有一定安全性。Objective:To investigate the curative effect of budesonide nebulization combined with ambroxol in the treatment of pediatric bronchopneumonia and its effect on serum CRP and PCT levels.Methods:A total of 186 children with bronchopneumonia treated in our hospital between June 2020 to September 2021 were enrolled and divided into observation group(n=93)and control group(n=93)by random number table method.The control group was treated with budesonide nebulization,while observation group was additionally treated with intravenous drip of ambroxol.The clinical curative effect after treatment,levels of inflammatory factors(CRP,PCT)and immune function(IgG,IgM,IgA)before and after treatment between the groups were compared.Results:After treatment,total response rate of observation group was higher than that of control group(93.55%vs 71.72%,P<0.05).After treatment,disappearance time of clinical symptoms was shorter in observation group than control group(P<0.05).After 5d of treatment,levels of CRP and PCT in both groups were decreased.The difference values of CRP and PCT before and after treatment in observation group were(25.93±4.54)mg/L and(1.03±0.25)μg/L,higher than those in control group[(16.15±3.72)mg/L,(0.84±0.19)μg/L,P<0.05].After 5d of treatment,levels of IgA,IgM and IgG in both groups were increased.The difference values of IgA,IgM and IgG before and after treatment in observation group were(4.15±0.87)g/L,(0.46±0.13)g/L and(0.63±0.22)g/L,higher than those in control group[(1.67±0.39)g/L,(0.27±0.06)g/L,(0.27±0.08)g/L,P<0.05].The incidence of adverse reactions between observation group and control group was similar the difference was not statistically significane[9.68%(9 cases)vs 7.53%(7 cases),P>0.05].Conclusion:Compared with budesonide nebulization alone,curative effect of budesonide nebulization combined with ambroxol is better on children with bronchopneumonia,which can more effectively improve clinical symptoms,inflammatory factors and immune function,with certain safety.

关 键 词：儿童 支气管肺炎 布地奈德 氨溴索 C反应蛋白 降钙素原 

分 类 号：R725.6[医药卫生—儿科]