莫西沙星左氧氟沙星序贯给药对老年重症慢性阻塞性肺疾病急性加重期患者呼吸功能微炎症的影响研究  

Effects of Sequential Administration of Moxifloxacin and Levofloxacin on Respiratory Function and Microinflammation in Elderly Patients with Severe AECOPD

作　　者：王超 陈晓君 宋晓莉 郭帅 WANG Chao(Sanya Central Hospital/Hainan Third People's Hospital,Hainan Sanya 572000,China)

机构地区：[1]海南省三亚市中心医院/海南省第三人民医院药学部,海南三亚572000 [2]海南省三亚市人民医院药学部,海南三亚572000

出　　处：《河北医学》2023年第4期685-689,共5页Hebei Medicine

基　　金：海南省卫生健康行业科研项目,(编号:21A200397)。

摘　　要：目的:研究莫西沙星、左氧氟沙星序贯给药对老年重症慢性阻塞性肺疾病急性加重期(AECOPD)患者呼吸功能、微炎症的影响。方法:选取2019年3月至2022年3月期间于我院接受治疗的老年重症AECOPD患者150例,将其应用简单随机法分为A组和B组、C组,每组各50例,A组给予莫西沙星治疗,B组给予左氧氟沙星治疗,C组给予莫西沙星、左氧氟沙星序贯给药。对比三组患者治疗1周后呼吸功能[第1秒用力呼气的容积占预计值的百分比(fev1%pred)、第1秒钟用力呼吸容积(FEV1)/用力肺活量(FVC)],比较分析三组治疗前后血清微炎症[细胞间黏附分子(ICAM)-1、干扰素γ可诱导的蛋白-10(IP-10)]、免疫功能[血浆可溶性髓样细胞触发受体-1(sTREM-1)、外周血CD4^(+)/CD8^(+)]变化情况,对比三组药物不良反应发生差异。结果:治疗1周后,三组fev1%pred、FEV1/FVC、外周血CD4^(+)/CD8^(+)上升,血清ICAM-1、IP-10、血浆sTREM-1下降,差异有统计学意义(P<0.05)。相同时间三组对比,A组fev1%pred、FEV1/FVC、外周血CD4^(+)/CD8^(+)较B组更高,血清ICAM-1、IP-10、血浆sTREM-1更低,C组较A、B两组fev1%pred、FEV1/FVC、外周血CD4^(+)/CD8^(+)更高,血清ICAM-1、IP-10、血浆sTREM-1更低,差异有统计学意义(P<0.05)。C组静脉炎发生率较A、B两组更低,差异有统计学意义(P<0.05)。其余不良反应发生差异则无统计学意义(P>0.05)。结论:莫西沙星、左氧氟沙星序贯给药可缓解AECOPD患者微炎症反应,改善其肺功能及免疫指标,还可有效预防静脉炎发生。Objective:To study the effects of sequential administration of moxifloxacin and levofloxacin on respiratory function and microinflammation in elderly patients with severe acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:150 elderly patients with severe AECOPD treated in our hospital from March 2019 to March 2022 were selected and divided into group A,B and C by simple random sampling method,with 50 cases in each group.Group A was given moxifloxacin,group B was given levofloxacin,and group C was given moxifloxacin and levofloxacin administered sequentially.The respiratory function indicators[forced expiratory volume in the first second as a percentage of the predicted value(fev1%pred)and forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC)]were compared among the three groups after 1 week of treatment,and the changes of serum microinflammation[intercellular cell adhesion molecule(ICAM)-1,interferon gamma-inducible protein-10(IP-10)]and immune function[plasma-soluble triggering receptor expressed on myeloid cells-1(sTREM-1),peripheral blood CD4^(+)/CD8^(+)]were compared and analyzed before and after treatment.The differences in occurrence of adverse drug reactions among the three groups were compared.Results:After 1 week of treatment,fev1%pred,FEV1/FVC and peripheral blood CD4^(+)/CD8^(+)were increased while serum ICAM-1,IP-10 and plasma sTREM-1 were decreased in the three groups the difference was statistically significant(P<0.05).Compared at the soone time the fev1%pred,FEV1/FVC and peripheral blood CD4^(+)/CD8^(+)in group A were higher while serum ICAM-1,IP-10 and plasma sTREM-1 were lower than those in group B,and fev1%pred,FEV1/FVC and peripheral blood CD4^(+)/CD8^(+)were higher while serum ICAM-1,IP-10 and plasma sTREM-1 were lower in group C compared to groups A and B the difference was statistically significant(P<0.05).The incidence rate of phlebitis in group C was lower than that in groups A and B the difference was statistically significant(P<0.05).There

关 键 词：莫西沙星 左氧氟沙星 序贯给药 老年重症慢性阻塞性肺疾病急性加重期 呼吸功能 微炎症 

分 类 号：R563.9[医药卫生—呼吸系统]