2020年四川省乐山市人民医院细菌分布及耐药分析  

Analysis of bacterial distribution and drug resistance in Leshan People′s Hospital of Sichuan Province in 2020

作　　者：唐艳[1] 杨建科[2] TANG Yan;YANG Jianke(Department of Pharmacy,Leshan People′s Hospital,Sichuan Province,Leshan 614000,China;不详)

机构地区：[1]四川省乐山市人民医院药学部,614000 [2]四川省乐山市人民医院医学检验科,614000

出　　处：《临床合理用药杂志》2023年第10期18-20,26,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的分析四川省乐山市人民医院2020年全院细菌分布及耐药性。方法选取四川省乐山市人民医院2020年1—12月送检临床标本内分离的2156株病原菌,对其进行原菌鉴定分析细菌分布,同时参考美国临床和实验室标准协会2019年标准分析耐药性。结果总共分离出2156株病原菌(真菌除外),革兰阴性菌1574株(73.0%),革兰阳性菌582株(27.0%)。大肠埃希菌对氨苄西林、复方新诺明、头孢唑啉、环丙沙星、头孢呋辛、舒巴坦、氨曲南及第3代头孢菌素存在较高耐药性,而对妥布霉素、哌拉西林、呋喃妥因、厄他培南、阿米卡星、亚胺培南、美洛培南及替加环素敏感性较高;肺炎克雷伯菌对氨苄西林耐药性最高,而对哌拉西林、厄他培南、亚胺培南、阿米卡星及美洛培南敏感性最高;铜绿假单胞菌对氨曲南、头孢他啶及哌拉西林耐药性较高,对妥布霉素、阿米卡星、亚胺培南及美洛培南敏感性最高;金黄色葡萄球菌对青霉素G、红霉素和克林霉素耐药性较高,对利福平、复方新诺明、呋喃妥因、利奈唑胺、达托霉素及万古霉素敏感性较高;凝固酶阴性葡萄球菌对青霉素G、红霉素及苯唑西林具有较高耐药性,对利福平、复方新诺明、达托霉素及万古霉素敏感性较高。结论该院2020年全院临床病原菌检测发现以革兰阴性菌为主,同时其耐药性明显提高,应增强对医院病原菌分布及耐药性的监测。Objective To analyze the bacterial distribution and drug resistance of pathogens in Leshan People′s Hospital of Sichuan Province in 2020.Methods 2156 strains of pathogenic bacteria isolated from clinical specimens submitted for examination by Leshan People′s Hospital of Sichuan Province from January to December in 2020 were selected,their original bacteria were identified,and the bacterial distribution was analyzed.At the same time,the drug resistance was analyzed with reference to the 2019 standard of American clinical and Laboratory Standards Association.Results A total of 2156 pathogenic bacteria(excluding fungi)were isolated,including 1574 gram-negative bacteria(73.0%)and 582 gram-positive bacteria(27.0%).Escherichia coli was highly resistant to ampicillin,compound sulfamethoxazole,cefazolin,ciprofloxacin,cefuroxime,sulbactam,aztreonam and third-generation cephalosporins,and was highly sensitive to tobramycin,piperacillin,furantoin,ertapenem,amikacin,imipenem,meropenem as well as tigecycline;Klebsiella pneumoniae had the high resistance to ampicillin,and had the high sensitivity to piperacillin,ertapenem,imipenem,amikacin and meropenem;Pseudomonas aeruginosa had high resistance to aztreonam,ceftazidime and piperacillin,and the high sensitivity to tobramycin,amikacin,imipenem and meropenem;Staphylococcus aureus showed high resistance to penicillin G,erythromycin and clindamycin,and high sensitivity to rifampicin,compound sulfamethoxazole,nitrofurantoin,linezolid,daptomycin and vancomycin;Coagulase-negative staphylococci were more resistant to penicillin G and erythromycin as well as oxacillin and sensitive to rifampicin,compound sulfamethoxazole,daptomycin and vancomycin.Conclusion In 2020,the clinical pathogenic bacteria in the hospital were mainly gram-negative bacteria,and their drug resistance was significantly increased,the monitoring of the distribution and drug resistance of pathogenic bacteria in the hospital should be strengthened.

关 键 词：细菌 耐药性分析 药敏试验 抗菌药物 

分 类 号：R446.5[医药卫生—诊断学]