男性血液透析患者勃起功能障碍调查及危险因素Logistic回归分析  

Logistic regression analysis of risk factors of erectile dysfunction in male patients undergoing hemodialysis

作　　者：徐艳[1] 张彬娥[1] 张旭珍[1] 张乾坤[1] 蒋丹罗兰 钭张琪 章巧庆[1] XU Yan;ZHANG Bin′e;ZHANG Xuzhen;ZHANG Qiankun;JIANG Danluolan;TOU Zhangqi;ZHANG Qiaoqing(Blood Purification Center,Lishui Central Hospital,Lishui 323000,Zhejiang,China)

机构地区：[1]丽水市中心医院血液净化中心,浙江丽水323000

出　　处：《中国性科学》2023年第4期29-32,共4页Chinese Journal of Human Sexuality

基　　金：浙江省医药卫生科技计划项目(2022ZH021)。

摘　　要：目的探究男性血液透析患者勃起功能障碍(ED)情况并分析其危险因素。方法选择2020年12月至2022年1月在丽水市中心医院行血液透析的男性患者153例,根据是否存在ED分为ED组(n=71)和无ED组(n=82)。收集患者的一般资料、血清学指标水平及性功能、抑郁生活质量评分,采用Logistic回归分析男性血液透析患者ED的危险因素。结果男性血液透析患者中46.41%发生ED,其中重度ED 36.62%、中度ED 43.66%、轻度ED 19.72%,患者出现不同程度的ED症状,如性欲下降、射精困难/早泄、性交疼痛、性高潮障碍。两组透析时间、白蛋白、血肌酐、血尿素氮、血清铁蛋白、吸烟情况比较,差异无统计学意义(P>0.05);两组年龄、血清总钙、血清磷、β-受体阻滞剂服用量、糖尿病情况、抑郁评分比较,差异具有统计学意义(P<0.05)。多元Logistic回归分析显示,年龄≥50岁、存在糖尿病、β-受体阻滞剂服用量较大、抑郁评分较高是男性血液透析患者存在ED的独立危险因素。ED组生理职能、情感职能、精神健康、躯体疼痛、精力评分以及SF-36总分低于无ED组,差异具有统计学意义(P<0.05);两组生理功能、社会功能、总体健康评分比较,差异无统计学意义(P>0.05)。结论男性血液透析患者46.41%发生ED,对于高龄、存在糖尿病、β-受体阻滞剂服用量较大以及抑郁患者应予以更多关注,及早进行干预。Objective To explore erectile dysfunction(ED)in male hemodialysis patients and analyze its risk factors.Methods A total of 153 male patients undergoing hemodialysis in Lishui Central Hospital were enrolled between December 2020 and January 2022.According to presence or absence of ED,they were divided into ED group(n=71)and non-ED group(n=82).The general data,serological indexes,scores of erectile function,depression and short form 36 questionnaire(SF-36)were collected.The risk factors of ED were analyzed by Logistic regression analysis.Results In the male patients undergoing hemodialysis,incidence of ED was 46.41%,including severe ED(36.62%),moderate ED(43.66%)and mild ED(19.72%).There were different degrees of ED symptoms,such as decreased libido,erectile disorders,ejaculation difficulty/premature ejaculation,dyspareunia and orgasm disorders.There was no significant difference in dialysis time,albumin,serum creatinine,urea nitrogen,ferritin or smoking between the two groups(P>0.05).But there were significant differences in age,total serum calcium,serum phosphorus,dosage ofβ-receptor antagonist,diabetes mellitus and depression score(P<0.05).Multivariate Logistic regression analysis showed that age≥50 years,diabetes mellitus,high-doseβ-receptor antagonist and high depression score were independent risk factors of ED in male patients undergoing hemodialysis.The scores of physiological role,emotional role,mental health,physical pain and energy,and total score of SF-36 in ED group were lower than those in non-ED group(P<0.05).But there was no significant difference in scores of physiological function,social function and overall health between the two groups(P>0.05).Conclusions In the male patients undergoing hemodialysis,incidence of ED is 46.41%.More attentions should be paid to patients with advanced age,diabetes mellitus,high-doseβ-receptor antagonist and depression.And early intervention should be carried out.

关 键 词：男性 血液透析 勃起功能障碍 LOGISTIC回归分析 生活质量 

分 类 号：R698[医药卫生—泌尿科学]