A biodegradable magnesium surgical staple for colonic anastomosis: In vitro and in vivo evaluation  

作　　者：Yue Zhang Jian Cao Mengmeng Lu Yi Shao Kewei Jiang Xiaodong Yang Xiaoyu Xiong Shan Wang Chenglin Chu Feng Xue Yingjiang Ye Jing Bai 

机构地区：[1]Jiangsu Key Laboratory for Advanced Metallic Materials,School of Materials Science and Engineering,Southeast University,Nanjing,211189,China [2]Institute of Biomedical Devices(Suzhou),Southeast University,Suzhou,215163,China [3]Department of Gastroenterological Surgery,Peking University People’s Hospital,Beijing,100044,China [4]Department of Oral Implantology,The Affiliated Stomatological Hospital of Nanjing Medical University,Nanjing,210029,China [5]Jiangsu Key Laboratory for Light Metal Alloys,Nanjing,211212,China

出　　处：《Bioactive Materials》2023年第4期225-238,共14页生物活性材料（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(51971062,81901056);the Natural Science Foundation of Jiangsu(BK20190649);the Science and Technology Project of Jiangsu Province(BE2019679);the Technological Innovation of key Industry of Suzhou(SYG202116);the open research fund of Jiangsu Key Laboratory for Advanced Metallic Materials(AMM2021A01).

摘　　要：Staplers have been widely used in the clinical treatment of gastrointestinal reconstruction.However,the current titanium(Ti)staple will remain in the human body permanently,resulting in some adverse effects.In this study,we developed a type of biodegradable staple for colonic anastomosis using 0.3 mm diameter magnesium(Mg)alloy wires.The wire surface was modified by micro-arc oxidation treatment(MAO)and then coated with poly-L-lactic acid(PLLA)to achieve a moderate degradation rate matching the tissue healing process.The results of tensile tests on isolated porcine colon tissue anastomosed by Mg and Ti staples showed that the anastomotic property of Mg staples was almost equal to that of Ti staples.The in vitro degradation tests indicated the dual-layer coating effectively enhanced the corrosion resistance and maintained the tensile force of the coated staple stable after 14-day immersion in the simulated colonic fluid(SCF).Furthermore,24 beagle dogs were employed to conduct a comparison experiment using Mg-based and clinical Ti staples for 90-day implantation by ent-to-side anastomosis of the colon.The integrated structure of Mg-based staples was observed after 7 days and completely degraded after 90 days.All animals did not have anastomotic leakage and stenosis,and 12 dogs with Mg-based staples fully recovered after 90 days without differences in visceral ion levels and other side effects.The favorable performance makes this Mg-based anastomotic staple an ideal candidate for colon reconstruction.

关 键 词：Gastrointestinal tract Degradation Bursting pressure Anastomotic stoma Colon reconstruction 

分 类 号：TG146.22[一般工业技术—材料科学与工程]