针刺对哮喘动物模型炎症、呼吸功能的影响及其相关机制研究  

Research on effects and relevant mechanism of acupuncture on inflammation and respiratory function in animal models of asthma

作　　者：孟琪 王雪玲 尹磊淼[2] MENG Qi;WANG Xueling;YIN Leimiao(Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China;Shanghai Research Institute of Acupuncture and Meridian,Shanghai 200030,China)

机构地区：[1]上海中医药大学,上海200030 [2]上海市针灸经络研究所,上海200030

出　　处：《上海中医药大学学报》2023年第2期22-27,40,共7页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(82274646,81922076);上海市教委、上海市教育发展基金会“曙光计划”项目(21SG44);上海市卫健委人才计划学科带头人培养项目(2022XD016)。

摘　　要：针刺是防治哮喘的常用方法之一,疗效确切,但其生物学机制非常复杂。为了阐明针刺治疗哮喘的具体机制,通过整理归纳针刺对哮喘模型气道炎症、肺组织病理和呼吸功能的影响及其可能的机制,发现针刺能够显著改善哮喘模型炎症细胞数量、肺组织病理变化和气道阻力升高。然而现有针刺哮喘动物模型及研究手段较单一,提示未来针刺哮喘基础研究应构建与中医证候相匹配的动物模型,机制研究手段应多元化。Acupuncture is one of the commonly used methods to prevent and treat asthma,and its efficacy is definite,but its biological mechanism is very complicated.In order to elucidate the specific mechanism of acupuncture treatment of asthma,the effects of acupuncture on airway inflammation,lung histopathology and respiratory function in asthma models and their possible mechanisms were collated and summarized,and it was found that acupuncture could significantly improve the number of inflammatory cells,lung histopathological changes and elevated airway resistance in asthma models.However,the existing animal models and research tools of acupuncture asthma are relatively single,suggesting that future basic research on acupuncture asthma should construct animal model matching syndromes of traditional Chinese medicine,and the mechanism research methods should be diversified.

关 键 词：针刺 支气管哮喘 动物模型 炎症 气道阻力 

分 类 号：R245[医药卫生—针灸推拿学]