Synthesis,Characterization and Application of Poly(lactic-co-glycolic acid)with a Mass Ratio of Lactic to Glycolic Segments of 52/48  

作　　者：QIN Chang DONG Jing XIE Beibei WANG Hongkun ZHANG Na ZHAO Chunhua QIAO Congde LIU Mingxia YANG Xiaodeng LI Tianduo 

机构地区：[1]Engineering Technology Center,Shandong Guyuchun Biotechnology Co.,Ltd.,Jinan,250098,P.R.China [2]Shandong Key Laboratory of Molecular Engineering,Qilu University of Technology,Shandong Academy of Sciences,Jinan,250353,P.R.China [3]Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,School of Pharmaceutical Sciences,Chongqing University,Chongqing,401331,P.R.China [4]Department of Blood Transfusion,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,250021,P.R.China

出　　处：《Chemical Research in Chinese Universities》2023年第2期290-295,共6页高等学校化学研究（英文版）

基　　金：Major Research and Development Project of Shandong Province,China(No.2019JZZY011118);Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province,China and the Project of the Jinan Science and Technology Bureau,China(No.2019GXRC021).

摘　　要：Poly(lactic-co-glycolic acid)(PLGA)is one of the most representative degradable copolymers and promising drug carriers.In the current paper,the PLGAs with a lactic acid/glycolic acid(LA/GA)molar ratio of 52/48 and various molecular weights were prepared by a melting method.The molecular weight,molecular weight distribution,and thermal stability were determined by 1H NMR and thermogravimetric analysis methods.The results demonstrated that PLGAs with the fixed LA/GA molar ratio(52/48),different molecular weights,and narrow molecular weight distribution could be obtained by solely altering the reaction time.The PLGA films were prepared,and their properties including micro-structure,mechanical property,in-vitro cytotoxicity,and biodegradability were characterized.In combination with the homogeneous microstructures and mechanical properties,the drug-loading and releasing properties of PLGA3.2 films were investigated.The results show that PLGA3.2 film with an LA/GA molar ratio of 52/48 is a promising curcumin carrier.

关 键 词：Poly(lactic-co-glycolic acid) Mechanical property PLGA film Drug carrier 

分 类 号：O63[理学—高分子化学]