清热解毒方联合二甲双胍对代谢综合征合并胰岛素抵抗患者炎症因子的影响  

Effects of QingReJieDu Recipe Combined with Metformin on Inflammatory Factors in Patients with Metabolic Syndrome Complicated with Insulin Resistance

作　　者：鲁晓篝 张意[1] 苑素云[1] 赵博 郑蓉[1] 张漫影 Lu Xiaogou;Zhang Yi;Yuan Suyun;Zhao Bo;Zheng Rong;Zhang Manying(Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《世界科学技术-中医药现代化》2022年第12期4745-4750,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：上海市卫生和计划生育委员会科研课题(20184Y0258):清热解毒方联合二甲双胍治疗代谢综合征胰岛素抵抗的临床研究;负责人:张意。

摘　　要：目的 观察清热解毒方联合二甲双胍对代谢综合征合并胰岛素抵抗患者炎症因子的影响。方法 选取上海中医药大学附属龙华医院、上海市浦东新区人民医院、上海市金山区中西医结合医院三所医院2019.1-2020.1收治的患者66例,应用随机数字按1∶1的比例分为实验组和对照组。对照组给予单纯二甲双胍治疗,实验组联合清热解毒方治疗,2组疗程均为8周。治疗后比较2组患者空腹血糖水平、胰岛素抵抗指数、炎症因子(白细胞介素-6(Interleukin 6,IL-6)、超敏C-反应蛋白(Hypersensitive C-reactive protein,hs-CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α))以及中医证候积分。结果 治疗8周后,2组患者空腹血糖水平、胰岛素抵抗指数、中医证候积分均较治疗前改善(P <0.05),且实验组改善优于对照组(P <0.05);两组患者TNF-α、IL-6水平均较治疗前改善,且实验组TNF-α水平低于对照组(P <0.05);同时实验组能够有效降低患者hs-CRP的炎症表达(P <0.05)。结论 清热解毒方联合二甲双胍治疗代谢综合征伴胰岛素抵抗患者较单纯使用二甲双胍治疗效果更显著,且能够降低患者空腹血糖水平、胰岛素抵抗指数及炎症因子(hs-CRP、TNF-α、IL-6)的表达,有效改善患者临床症状,值得临床推广。Objective To observe the effects of QingReJieDu Recipe combined with metformin on inflammatory factors in patients with metabolic syndrome complicated with insulin resistance.Methods From January 2019 to January 2020,66 patients who were admitted to Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai Pudong New Area People’s Hospital and Shanghai Jinshan District Hospital of Integrated Traditional Chinese and Western Medicine Hospital were enrolled.Patients were randomly divided into experimental group and control group according to the ratio of 1∶ 1.The control group was treated with metformin alone,and the experimental group was treated with QingReJieDu Recipe.The course of treatment of both groups was 8 weeks.After treatment,The fasting blood glucose level,insulin resistance index,inflammatory factors(hs-CRP,TNF-α、IL-6) and traditional Chinese medical syndrome score were compared between the two groups.Results After 8 weeks of treatment,the fasting blood glucose level,insulin resistance index and the traditional Chinese medical syndrome score in the two groups were improved compared with those before treatment(P < 0.05),and the improvements in the experimental group were better than these of the control group(P < 0.05);The levels of TNF-α,L-6 were improved in two groups compared with those before treatment,and The level of TNF-α in the experimental group was lower than that in the control group(P < 0.05);at the same time,the experimental group could effectively reduce the inflammatory expression of hs-CRP(P < 0.05).Conclusion QingReJieDu Recipe combined with metformin is more effective in the treatment of metabolic syndrome with insulin resistance than metformin alone,and can reduce the fasting blood glucose level,insulin resistance index and the expression of inflammatory factors(hs-CRP,TNF-α、 IL-6).It can effectively improve the clinical symptoms of patients,which is worthy of clinical promotion.

关 键 词：清热解毒方 代谢综合征 胰岛素抵抗 炎症因子 疗效 

分 类 号：R285.6[医药卫生—中药学]