补肾化浊解毒汤治疗闭塞性动脉硬化症的疗效观察及对血脂、炎症指标的影响  

Observation on Clinical Efficacy of Bushen Huazhuo Jiedu Decoction in Treating Arteriosclerosis Obliterans and Influence on Blood Lipid and Inflammatory Index

作　　者：靖金鹏 张玥[2] 安震 李环[2] 唐卫荷 Jing Jinpeng;Zhang Yue;An Zhen;Li Huan;Tang Weihe(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Rizhao Hospital of Traditional Chinese Medicine,Rizhao 276800,China;First Clinical Medical School,Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]天津中医药大学研究生院,天津3301617 [2]山东中医药大学附属医院,济南250014 [3]日照市中医医院,日照276800 [4]山东中医药大学第一临床医学院,济南250014

出　　处：《世界科学技术-中医药现代化》2022年第12期4935-4941,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：山东省中医药管理局中医药科技发展计划项目(2019-0205):基于肾虚浊毒理论探讨补肾化浊解毒汤治疗ASO的疗效评价,负责人:张玥;山东省中医药管理局中医药科技发展计划项目(2019-0157):基于健康管理的闭塞性动脉硬化症患者中医护理应用研究,负责人:李环。

摘　　要：目的观察补肾化浊解毒汤治疗闭塞性动脉硬化症(Arteriosclerosis obliterans,ASO)的临床疗效及其对炎症、血脂指标的影响。方法选取2020年1月-2020年12月于山东中医药大学附属医院周围血管病科住院治疗的ASO患者60例,随机分为试验组和对照组各30例。试验组在对照组常规治疗方案的基础上加用补肾化浊解毒汤治疗。记录两组患者治疗前后的临床疗效,中医证候积分、炎症指标[超敏C-反应蛋白(High sensitive C reactive protein,hs-CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)]、血脂指标[总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)、脂蛋白α[Lipoproteinα,Lp(α)]、高密度脂蛋白(High density lipoprotein,HDL)、低密度脂蛋白(Low density lipoprotein,LDL)]和踝臂指数(Ankle-brachial index,ABI)的变化,并记录不良反应发生情况。结果试验组的总有效率和显愈率较对照组高(P<0.05,P<0.01);与治疗前相比,两组患者治疗后的中医证候积分、hs-CRP、TNF-α、TC、LDL和Lp(α)水平均降低(P<0.05,P<0.01),HDL和ABI水平均升高(P<0.05,P<0.01);试验组的中医症状积分、hs-CRP、TNF-α、TC和LDL水平均低于对照组(P<0.05,P<0.01),而HDL水平高于对照组(P<0.05)。两组患者在治疗过程中均未出现不良反应。结论补肾化浊解毒汤治疗ASO安全有效,可通过抑制患者炎症反应,改善血脂水平等作用机制发挥临床疗效。Objective To observe the clinical efficacy of Bushen Huazhuo Jiedu Decoction in treating arteriosclerosis obliterans(ASO)and its effect on inflammation and blood lipid indexes.Results A total of 60 ASO patients hospitalized in the hospital from January 2020 to December 2020 were selected and divided into observation group and control group according to random number table method(30 cases in each group).The control group was treated with routine treatment,and the observation group was treated with Bushen Huazhuo Jiedu Decoction.The clinical efficacy of the two groups before and after treatment was recorded.The changes of TCM symptom score,inflammation index(hs-CRP,TNF-α),blood lipid index[total cholesterol(TC),triglyceride(TG),lipoprotein(α)[Lp(α)],high density lipoprotein(HDL),low density lipoprotein(LDL)]and ankle brachial index(ABI)And the occurrence of adverse reactions was recorded.Methods The total effective rate and obvious healing rate in observation group were higher than those in control group(P<0.05,P<0.01).Compared with before treatment,TCM symptom score,hs-CRP,TNF-α,TC,LDL and Lp(α)levels were decreased after treatment(P<0.05,P<0.01),HDL and ABI levels were increased(P<0.05,P<0.01).The TCM syndrome score,hs-CRP,TNF-α,TC and LDL levels in the observation group were lower than those in the control group(P<0.05,P<0.01),while the HDL level was higher than that in the control group(P<0.05).There were no adverse reactions in two groups during the treatment.Conclusion Bushen Huazhuo Jiedu Decoction is safe and effective in the treatment of ASO,and can play a clinical effect by inhibiting inflammatory response and improving blood lipid level.

关 键 词：闭塞性动脉硬化症 肾虚浊毒 补肾化浊解毒汤 临床疗效 

分 类 号：R285.6[医药卫生—中药学]