Global patterns of phylogenetic diversity and transmission of bat coronavirus  

作　　者：Zhilin Wang Guangping Huang Mingpan Huang Qiang Dai Yibo Hu Jiang Zhou Fuwen Wei 

机构地区：[1]CAS Key Laboratory of Animal Ecology and Conservation Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China [4]School of Karst Science,Guizhou Normal University,Guiyang 550000,China [5]Center for Evolution and Conservation Biology,Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou),Guangzhou 511458,China

出　　处：《Science China(Life Sciences)》2023年第4期861-874,共14页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(32192420);the Special Foundation for National Science and Technology Basic Research Program of China(2021FY100304)。

摘　　要：Bats are reservoirs for multiple coronaviruses(Co Vs).However,the phylogenetic diversity and transmission of global bat-borne Co Vs remain poorly understood.Here,we performed a Bayesian phylogeographic analysis based on 3,594 bat Co V Rd Rp gene sequences to study the phylogenetic diversity and transmission of bat-borne Co Vs and the underlying driving factors.We found that host-switching events occurred more frequently forα-Co Vs than forβ-Co Vs,and the latter was highly constrained by bat phylogeny.Bat species in the families Molossidae,Rhinolophidae,Miniopteridae,and Vespertilionidae had larger contributions to the cross-species transmission of bat Co Vs.Regions of eastern and southern Africa,southern South America,Western Europe,and Southeast Asia were more frequently involved in cross-region transmission events of bat Co Vs than other regions.Phylogenetic and geographic distances were the most important factors limiting Co V transmission.Bat taxa and global geographic hotspots associated with bat Co V phylogenetic diversity were identified,and bat species richness,mean annual temperature,global agricultural cropland,and human population density were strongly correlated with the phylogenetic diversity of bat Co Vs.These findings provide insight into bat Co Vevolution and ecological transmission among bat taxa.The identified hotspots of bat Co V evolution and transmission will guide early warnings of bat-borne Co V zoonotic diseases.

关 键 词：BAT CORONAVIRUS ecological transmission phylogenetic diversity driving factors 

分 类 号：F49[经济管理—产业经济]