Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences  

作　　者：Lei Pang Xi Jiang Xin Lian Jie Chen Er-Fei Song Lei-Gang Jin Zheng-Yuan Xia Hai-Chun Ma Yin Cai 

机构地区：[1]Department of Anesthesiology,the First Hospital of Jilin University,Changchun 130021,China [2]Health Promotion Center,the First Hospital of Jilin University,Changchun 130021,China [3]Department of Urology,the First Hospital of Jilin University,Changchun 130021,China [4]Henry Fok School of Biology and Agriculture,Shaoguan University,Shaoguan 512000,Guangdong,China [5]Department of Metabolic and Bariatric Surgery,Jinan University First Affiliated Hospital,Guangzhou 510630,China [6]Department of Medicine,LKS Faculty of Medicine,the University of Hong Kong,Hong Kong,China [7]State Key Laboratory of Pharmaceutical Biotechnology,LKS Faculty of Medicine,the University of Hong Kong,Hong Kong,China [8]Department of Anesthesiology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,China [9]Department of Health Technology and Informatics,the Hong Kong Polytechnic University,Hong Kong,China

出　　处：《Military Medical Research》2023年第1期113-133,共21页军事医学研究（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(81800245,81970228,82102306,81900779);the China Postdoctoral Science Foundation(2020M670030ZX);the Shaoguan Science and Technology Program(2019sn078);the Start-up Fund for RAPs under the Strategic Hiring Scheme(P0035913)。

摘　　要：The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease(CVD). This is achieved by preventing cardiac hypertrophy and protecting blood vessels through improving the function of endothelium. However, do these interventions work in the aged human hearts? Cardiac aging is accompanied by an increase in left ventricular hypertrophy, along with diastolic and systolic dysfunction. It also confers significant cardiovascular risks for both sexes. The incidence and prevalence of CVD increase sharply at an earlier age in men than women. Furthermore, the patterns of heart failure differ between sexes, as do the lifetime risk factors. Do caloric restriction(CR)-mimetics, rich in polyphenol or polyamine, delay or reverse cardiac aging equally in both men and women? This review will discuss three areas:(1) mechanisms underlying age-related cardiac remodeling;(2) gender-related differences and potential mechanisms underlying diminished cardiac response in older men and women;(3) we select a few polyphenol or polyamine rich compounds as the CRmimetics, such as resveratrol, quercetin, curcumin, epigallocatechin gallate and spermidine, due to their capability to extend health-span and induce autophagy. We outline their abilities and issues on retarding aging in animal hearts and preventing CVD in humans. We discuss the confounding factors that should be considered for developing therapeutic strategies against cardiac aging in humans.

关 键 词：Cardiovascular disease Cardiac aging Caloric restriction Gender difference Caloric restriction-mimetics Dietary compounds Clinical application 

分 类 号：R541.6[医药卫生—心血管疾病]