自然杀伤细胞在子宫内膜异位症免疫调节中的研究进展  

Research progress of natural killer cells in immune regulation of endometriosis

作　　者：姚军 张丽姣 花茂方[1] Yao Jun;Zhang Lijiao;Hua Maofang(Department of Gynecology,Lianyungang Maternity and Child Care Hospital,Lianyungang 222000,China;Yangzhou University Medical College,Yangzhou 225000,China)

机构地区：[1]连云港市妇幼保健院妇科,江苏连云港222000 [2]扬州大学医学院,江苏扬州225000

出　　处：《国际免疫学杂志》2023年第1期98-102,共5页International Journal of Immunology

基　　金：连云港市妇幼保健院青年英才培养基金资助项目(ky202005);复旦大学附属妇产医院上海市女性生殖内分泌相关疾病重点实验室开放课题基金资助项目(17DZ2273600)。

摘　　要：子宫内膜异位症(endometriosis,EMs)是子宫内膜样组织在子宫以外存在和生长。EMs存在免疫细胞浸润、巨噬细胞活化和自然杀伤细胞(natural killer,NK)毒性异常,以及促炎性和调节性细胞因子的异常表达等。越来越多的研究证据表明EMs的发生与NK细胞毒性异常有关。文章概述了EMs患者NK细胞的毒性异常与NK细胞受体异常表达相关研究及基于NK细胞相关受体干预的EMs免疫治疗。Endometriosis(EMs)is the presence and growth of endometrioid tissue outside the uterus.EMs has abnormal immune cell infiltration,macrophage activation,natural killer(NK)cytotoxicity,and abnormal expression of proinflammatory and regulatory cytokines.More and more research evidence shows that the occurrence of EMs is related to abnormal NK cytotoxicity.This review summarized the research on abnormal cytotoxicity of NK cells and abnormal expression of NK cell receptors in patients with EMs,and the immunotherapy of EMs based on the intervention of NK cell related receptors.

关 键 词：子宫内膜异位症 自然杀伤细胞 免疫 

分 类 号：R711.71[医药卫生—妇产科学]