环境污染物暴露与儿童自闭症的研究进展  

Research progress on environmental pollutant exposure and childhood autism

作　　者：赵启源 冉秀芳 王苏苏 颜崇淮[1] ZHAO Qiyuan;RAN Xiufang;WANG Susu;YAN Chonghuai(MOE-Shanghai Key Laboratory of Children′s Environmental Health,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院教育部和上海市环境与儿童健康重点实验室,上海200092

出　　处：《中国妇幼健康研究》2023年第4期60-66,共7页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金资助项目(81973062)。

摘　　要：自闭症谱系障碍(ASD)是一种神经发育障碍性疾病,主要表现为社交和沟通障碍、兴趣狭窄、重复性及刻板行为,导致儿童的记忆、思维和学习能力缺陷。近年来,ASD的发病率明显增加。环境污染物如重金属、持久性有机污染物与空气污染物等在ASD发病中可能发挥的作用逐渐引起了广泛关注。本文回顾了铅、汞、镉、砷、部分持续性有机污染物、空气污染和农药等常见环境污染物与ASD关系的现有研究成果,并就目前环境污染物和ASD发病的相关机制(包括氧化应激、神经胶质细胞改变、突触结构功能改变等)进行论述,以期对ASD有更深入的认识,并提供新的研究窗口。Autism spectrum disorder(ASD)is a neurodevelopmental disorder characterized by social and communication impairment,narrow interests,repetitive and stereotyped behaviors,resulting in deficits in memory,thinking and learning in children.In recent years,the incidence of ASD has increased significantly.The possible roles of environmental pollutants such as heavy metals,persistent organic pollutants and air pollutants in the pathogenesis of ASD have gradually attracted widespread attention.This paper reviewed the existing research results on the relationship between the common environmental pollutants such as lead,mercury,cadmium,arsenic,some persistent organic pollutants,air pollution and pesticides,and ASD,and discussed the current related mechanisms of environmental pollutants and ASD pathogenesis(including oxidative stress,glial cell changes,synaptic structure and function changes,etc.),so as to have a deeper understanding of ASD and provide a new research window.

关 键 词：自闭症 环境污染物 汞 铅 持续性有机污染物 氧化应激 

分 类 号：R179[医药卫生—妇幼卫生保健]