支气管哮喘儿童GO/NOGO范式实验执行功能及其与肺功能的相关性分析  

Executive Function of GO/NOGO Paradigm Experiment in Children with Bronchial Asthma and Its Relationship with Pulmonary Function

作　　者：李静波 庞高峰[1] 任艳玲[1] 沙曦雪 倪慧萍[1] LI Jingbo;PANG Gaofeng;REN Yanling;SHA Xixue;NI Huiping(Department of Pediatric,the Third Affiliated Hospital of Soochow University(the First People's Hospital of Changzhou),Changzhou 213003,China)

机构地区：[1]苏州大学附属第三医院(常州市第一人民医院)儿科,江苏省常州市213003

出　　处：《中国全科医学》2023年第20期2503-2507,共5页Chinese General Practice

基　　金：常州市应用基础研究计划资助课题项目(CJ20122016);江苏省妇幼保健协会科研课题(FYX202021)。

摘　　要：背景哮喘儿童的执行功能方面存有缺陷会影响患儿的生活质量和心理健康,执行功能与肺功能之间关系的研究较少。目的研究支气管哮喘儿童是否存有执行功能障碍及其具体表现形式;探讨支气管哮喘儿童执行功能与肺功能检测指标的关系。方法选取2020年6月—2022年4月就诊于苏州大学附属第三医院(常州市第一人民医院)儿科门诊且被诊断为支气管哮喘的儿童35例为哮喘儿童组,同时纳入苏州大学附属第三医院(常州市第一人民医院)儿科门诊就诊的健康儿童35例为健康对照组,采用GO/NOGO范式实验收集执行功能指标,并检测其肺功能,采用Pearson相关分析与Spearman秩相关分析探讨执行功能指标与肺功能检测指标的关系。结果哮喘儿童组击中数低于健康对照组,反应时间、反应时间变异性、漏报错误数高于健康对照组(P<0.05)。Pearson相关分析/Spearman秩相关分析结果显示,哮喘儿童反应时间与最大肺活量(VCmax)、用力肺活量(FVC)呈负相关,反应时间变异性与VCmax、FVC、第1秒用力呼气容积呈负相关,漏报错误数与用力肺活量占预计值百分比呈正相关(P<0.05)。结论与健康儿童相比,哮喘儿童持续注意力、反应速度存在障碍,哮喘儿童的执行功能障碍与肺功能检测指标具有相关性,主要表现在持续注意力、反应速度降低。Background Children with asthma may have deficits in executive functioning,affecting the quality of life and mental health of children.However,there are few studies on the relationship between executive function and pulmonary function.Objective To investigate whether executive dysfunction is comorbid and its specific manifestations and analyze the relationship between executive function and pulmonary function in children with bronchial asthma.Methods A total of 35 children diagnosed with bronchial asthma in the pediatric outpatient of the Third Affiliated Hospital of Soochow University(the First People's Hospital of Changzhou)from June 2020 to April 2022 were selected as the children with asthma group,and 35 healthy children were included in the pediatric outpatient of the Third Affiliated Hospital of Soochow University(the First People's Hospital of Changzhou)as the healthy control group.The GO/NOGO experiment was used to collect the executive function indexes and detect the pulmonary function.Pearson correlation analysis and Spearman rank correlation analysis were used to explore the relationship between executive function indexes and pulmonary function test indices.Results The number of hits in the children with asthma group was lower than that in the healthy control group,and the response time,response time variability and missed reporting errors were higher than those in healthy control group(P<0.05).The results of Pearson correlation analysis/Spearman rank correlation analysis showed that response time was negatively correlated with maximum vital capacity(VCmax)and forced vital capacity(FVC)in children with asthma,and response time variability was negatively correlated with VCmax,FVC and forced expiratory volume in one second(P<0.05).The number of missed reports was positively correlated with percent predicted forced vital capacity(P<0.05).Conclusion Compared with healthy children,children with asthma perform sustained attentional deficits and reaction rate deficits,and the executive function indexes of chi

关 键 词：支气管哮喘 儿童健康 执行功能 呼吸功能试验 相关性研究 GO/NOGO范式实验 

分 类 号：R562.25[医药卫生—呼吸系统] R395.9[医药卫生—内科学]