新疆地区癫痫患儿拉考沙胺稳态血药浓度的影响因素及参考范围初探  

Factors Affecting Steady-State Plasma Concentration of Lacosamide in Children with Epilepsy in Xinjiang and Preliminary Establishment of Reference Range

作　　者：于静 何磊 帕拉提·热合曼 冯继荣 孙岩 Yu Jing;He Lei;Palati·Reheman;Feng Jirong;Sun Yan(Children’s Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Hospital of Beijing Children’s Hospital,Urumqi 830000,China)

机构地区：[1]新疆维吾尔自治区儿童医院,北京儿童医院新疆医院,乌鲁木齐830000

出　　处：《儿科药学杂志》2023年第4期7-10,共4页Journal of Pediatric Pharmacy

基　　金：中国抗癫痫协会-CAAE癫痫科研基金-UCB基金,编号CU-2022-032。

摘　　要：目的:探讨新疆地区癫痫患儿拉考沙胺(LCM)稳态血药浓度的影响因素,初步建立LCM稳态血药浓度的参考范围,为临床个体化用药提供参考。方法:收集新疆地区规律服用LCM并达到稳态血药浓度的4~14岁癫痫患儿313例,测定血药浓度,分析年龄、性别、民族、剂量、合并用药等因素对血药浓度的影响,并初步建立稳态血药浓度的参考范围。结果:新疆地区癫痫患儿的LCM浓度剂量比(CDR)无性别和民族差异(P>0.05);4~6岁组给药剂量高于7~14岁组,而CDR低于7~14岁组(P均<0.01);LCM单药组给药剂量和血药浓度低于LCM+其他抗癫痫药物组(P均<0.05)。总体LCM稳态血药浓度参考范围为2.02~14.47μg/mL。结论:临床使用LCM控制和治疗儿童癫痫的过程中,有必要进行治疗药物监测,以便及时调整剂量,更好地控制癫痫发作。Objective:To explore the factors affecting the steady-state plasma concentration of lacosamide(LCM)in children with epilepsy in Xinjiang,and to establish the reference range of steady-state plasma concentration of LCM,so as to provide theoretical basis for clinical individualized drug use.Methods:The serum drug concentration was collected and measured in 313 children with epilepsy in Xinjiang who regularly took LCM and reached steady-state blood concentration,and the effects of age,gender,ethnicity,dosage and combined use on the serum concentration of LCM were analyzed,and the reference range of steady-state serum concentration of LCM was preliminarily established.Results:There was no significant difference in LCM concentration-dose ratio(CDR)values among children with epilepsy of different genders and ethnic groups(P>0.05).The dosage of the 4 to 6 age group was significantly higher than that of the 7 to 14 age group,and the CDR results of the 7 to 14 age group were significantly higher than that of the 4 to 6 age group(all P<0.01).The concentration results of the children in the LCM single drug group were significantly lower than those of the LCM combined with other antiepileptic drugs groups(all P<0.05).The reference range of steady-state blood concentration of LCM in this study was 2.02-14.47μg/mL.Conclusion:During the clinical use of LCM to control and treat epilepsy in children,it is necessary to monitor the therapeutic drug of LCM in order to adjust its dosage in time and better control epileptic seizures.

关 键 词：癫痫 儿童 拉考沙胺 血药浓度 参考范围 

分 类 号：R969.3[医药卫生—药理学]