Inorganic hollow mesoporous spheres-based delivery for antimicrobial agents  

作　　者：Yunping Qiao Yanyang Han Rengui Guan Shiliang Liu Xinling Bi Shanshan Liu Wei Cui Tao Zhang Tao He 

机构地区：[1]Department of Applied Chemistry,School of Chemistry and Chemical Engineering,Yantai University,Clearspring RD 3Oth,Laishan,Yantai 264005,China [2]Weifang Branch Company,Shandong Hl-speed Transportation Construction Group Co.,Ltd.,Qingzhou 262500,China [3]Shandong Jinhai Titanium Resources Technology Co.,Ltd.,Binzhou 256600,China

出　　处：《Frontiers of Materials Science》2023年第1期51-68,共18页材料学前沿（英文版）

基　　金：This work was financially supported by the project ZR2020MB069 supported by the Shandong Provincial Natural Science Foundation.T.Z.thanks the generous funding support from the Shandong Provincial Natural Science Foundation(ZR2020QB163);the Taishan Scholars Program of Shandong Province,China(No.tsqn201909083).

摘　　要：Microorganisms coexist with human beings and have formed a complex relationship with us.However,the abnormal spread of pathogens can cause infectious diseases thus demands antibacterial agents.Currently available antimicrobials,such as silver ions,antimicrobial peptides and antibiotics,have diverse concerns in chemical stability,biocompatibility,or triggering drug resistance.The“encapsulate-and-deliver”strategy can protect antimicrobials against decomposing,so to avoid large dose release induced resistance and achieve the controlled release.Considering loading capacity,engineering feasibility,and economic viability,inorganic hollow mesoporous spheres(iHMSs)represent one kind of promising and suitable candidates for real-life antimicrobial applications.Here we reviewed the recent research progress of iHMSs-based antimicrobial delivery.We summarized the synthesis of iHMSs and the drug loading method of various antimicrobials,and discussed the future applications.To prevent and mitigate the spread of an infective disease,multilateral coordination at the national level is required.Moreover,developing effective and practicable antimicrobials is the key to enhancing our capability to eliminate pathogenic microbes.We believe that our conclusion will be beneficial for researches on the antimicrobial delivery in both lab and mass production phases.

关 键 词：antimicrobial inorganic hollow mesoporous sphere encapsulate-and-deliver drug delivery 

分 类 号：TB383[一般工业技术—材料科学与工程]