“胃十针”结合多潘立酮片治疗胃肠神经官能症伴失眠症的临床研究  

Clinical study on the treatment of gastrointestinal neurosis with insomnia by combination of"stomach ten acupuncture"and domperidone tablets

作　　者：钱子成 崔璀 王菲 王充 曹亚美 孙贤 张姝媛 张桂睿[1] 周贵福[1] Qian Zicheng;Cui Cui;Wang Fei;Wang Chong;Cao Yamei;Sun Xian;Zhang Shuyuan;Zhang Guirui;Zhou Guifu(First Department of Encephalopathy,East Hospital,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]石家庄市中医院东院区脑病一科,石家庄050000

出　　处：《国际中医中药杂志》2023年第4期415-420,共6页International Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2021271)。

摘　　要：目的基于“胃不和则卧不安”理论探讨“胃十针”结合多潘立酮片对胃肠神经官能症伴失眠症患者临床症状及睡眠质量的影响。方法随机对照试验设计。将符合入选标准的2020年3月-2021年3月本院98例胃肠神经官能症伴失眠症患者,采用随机数字表法分为2组,每组49例。对照组口服多潘立酮片,观察组在对照组基础上辅以“胃十针”治疗。2组均治疗8周。分别于治疗前后进行中医证候评分,采用胃肠道症状评定量表(GSRS)评估胃肠道症状的严重程度,汉密尔顿焦虑量表(HAMA)与汉密尔顿抑郁量表(HAMD)评估焦虑和抑郁程度,匹兹堡睡眠质量指数量表(PSQI)评估睡眠质量。结果治疗后,观察组胃脘疼痛、嗳气、脘腹痞胀、食少纳呆、嘈杂反酸、倦怠乏力、大便黏滞不爽或便溏评分及总分低于对照组(t值分别为19.61、19.30、23.10、22.05、20.43、21.81、20.51、16.38,P<0.01);典型症状、腹痛症状、反流症状、腹泻症状、便秘症状评分及总分低于对照组(t值分别为10.10、11.14、11.04、9.31、11.24、5.30,P<0.01);HAMA、HAMD评分低于对照组(t值分别为6.96、6.85,P<0.01);入睡时间[(1.15±0.56)分比(2.11±0.75)分,t=7.18]、睡眠时间[(0.92±0.63)分比(1.52±1.12)分,t=3.27]、睡眠质量[(1.02±0.66)分比(1.96±0.80)分,t=6.35]、睡眠效率[(0.86±0.62)分比(1.68±0.85)分,t=5.46]、睡眠障碍[(0.92±0.36)分比(1.48±0.55)分,t=5.96]、日间功能障碍[(0.96±0.42)分比(1.97±0.87)分,t=7.32]、催眠药物[(0.98±0.45)分比(1.81±0.62)分,t=7.58]评分及总分[(6.85±1.47)分比(12.73±2.95)分,t=12.49]低于对照组(P<0.01)。结论“胃十针”结合多潘立酮片可有效改善胃肠神经官能症伴失眠症患者的临床症状和睡眠质量。Objective To study on the effect of"stomach ten acupuncture"combined with domperidone tablets on clinical symptoms and sleep quality of gastrointestinal neurosis patients with insomnia based on the theory of"stomach harmonious leading to restless".Methods Randomized controlled trial.From March 2020 to March 2021,98 patients with gastrointestinal neurosis and insomnia in our hospital who met the inclusion criteria were randomly divided into two groups,with 49 patients in each group.The control group took domperidone tablets orally,and the observation group was treated with"stomach ten acupuncture"on the basis of the control group.Both groups were treated for 8 weeks.Before and after treatment,TCM syndromes were scored,the severity of gastrointestinal symptoms was assessed with Gastrointestinal Symptom Rating Scale(GSRS),anxiety and depression were assessed with Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),and sleep quality was assessed with Pittsburgh Sleep Quality Index Scale(PSQI).Results After treatment,the scores and total scores of epigastric pain,belching,abdominal distension,anorexia,noisy acid regurgitation,tiredness and asthenia,constipation and loose stools in the observation group were significantly lower than those in the control group(t values were 19.61,19.30,23.10,22.05,20.43,21.81,20.51,16.38,respectively,P<0.01);the scores and total scores of typical symptoms,abdominal pain symptoms,reflux symptoms,diarrhea symptoms,constipation symptoms were significantly lower than those in the control group(t values were 10.10,11.14,11.04,9.31,11.24,5.30,respectively,P<0.01);HAMA and HAMD scores were significantly lower than those in the control group(t values were 6.96 and 6.85,respectively,P<0.01).The scores of time to fall asleep(1.15±0.56 vs.2.11±0.75,t=7.18),time to sleep(0.92±0.63 vs.1.52±1.12,t=3.27),sleep quality(1.02±0.66 vs.1.96±0.80,t=6.35),sleep efficiency(0.86±0.62 vs.1.68±0.85,t=5.46),sleep disorders(0.92±0.36 vs.1.48±0.55,t=5.96),daytime dysfunction(0.96±0.42 vs.1.97

关 键 词：神经症性障碍 胃肠神经官能症 失眠症 胃十针 复发 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R740[医药卫生—临床医学]