儿童血浆鸢尾素浓度与血压变化关系的队列研究  

Association between plasma Irisin concentrations and changes in blood pressure among children:a cohort study

作　　者：谈敏怡 胡艳 宋燕燕 曾霞 桂曌环 吴生池 陈亚军 蔡莉 TAN Minyi;HU Yan;SONG Yanyan;ZENG Xia;GUI Zhaohuan;WU Shengchi;CHEN Yajun;CAI Li(Department of Children Healthcare,Guangzhou Women and Children's Medical Center/Guangdong Provincial Clinical Research Center for Child Health,Guangzhou(510623),China;不详)

机构地区：[1]广州市妇女儿童医疗中心儿童保健部/广东省儿童健康与疾病临床医学研究中心,广东510623 [2]中山大学公共卫生学院妇幼卫生学系

出　　处：《中国学校卫生》2023年第3期419-422,427,共5页Chinese Journal of School Health

基　　金：国家自然科学基金面上项目(81673193);广东省自然科学基金面上项目(2019A1515011462)。

摘　　要：目的分析儿童血浆鸢尾素(Irisin)质量体积浓度与血压变化的关联,并探讨体力活动(PA)和静态行为(SB)在该关联中的调节作用,为儿童高血压防治提供科学依据。方法采用前瞻性队列研究设计,2017年在广州市随机抽取5所小学共3651名儿童进行问卷调查和体格检查,并于2019年随访。基线和随访均使用国际体力活动问卷调查PA和SB,采用电子血压计测量血压,根据基线的PA和SB数据筛选出符合标准的儿童,最终共有521名儿童纳入研究,对纳入的儿童采用ELISA方法测定基线血浆Irisin浓度。采用有序多分类Logistic回归分析Irisin质量体积浓度与血压变化的关联,通过分层分析探究PA和SB对上述关联的调节作用。结果研究对象总体中,血浆Irisin质量体积浓度与血压变化无明显关联(OR=0.98,P>0.05)。根据SB水平进行分层,在低SB水平的儿童中Irisin质量体积浓度与舒张压(DBP)变化呈负相关(OR=0.87,95%CI=0.77~0.98,P=0.02)。SB水平对Irisin浓度与DBP水平变化之间的相关性具有调节作用(P=0.01)。结论在低SB水平儿童中,较高Irisin水平与DBP水平降低相关,SB水平是Irisin质量体积浓度与DBP水平变化间关系的调节因素。Objective To investigate the longitudinal association of plasma Irisin concentrations with changes in blood pressure(BP)levels among children,and to assess the moderating effect of physical activity(PA)or sedentary behavior(SB)on the relationship between Irisin levels and BP.Methods Based on a cohort study,a cluster sampling method was used to select 3651 school-aged children from five schools in Guangzhou in 2017 at the baseline survey and follow-up in 2019.Both at baseline and during follow-up,PA and SB were assessed by validated questionnaires,and BP levels were measured by an electronic sphygmomanometer.A final sample of 521 children were enrolled based on the PA and SB at baseline.Plasma Irisin concentrations were measured by ELISA at baseline.Logistic regression analysis was recruited for exploring the associations of plasma Irisin concentrations with changes in BP.Moderating effects of PA and SB on the relationship between Irisin concentrations and BP were estimated using stratified analysis.Results Logistic regression analysis indicated that there was no significant association between Irisin concentrations and changes in BP levels among children(OR=0.98,P>0.05).After stratification for SB,Irisin levels in the low SB subgroup were inversely associated with changes in diastolic blood pressure(OR=0.87,95%CI=0.77-0.98,P=0.02).In addition,SB level had a moderating effect on the relationship between Irisin levels and the DBP changes(P=0.01).Conclusion Increased Irisin concentration is associated with the decrease of DBP level among low SB children.Furthermore,SB level shows moderating role in the relationship between Irisin concentrations and changes in DBP levels.

关 键 词：鸢尾素 血浆 血压 队列研究 回归分析 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健] R544[医药卫生—公共卫生与预防医学]