Nano-calcium silicate mineralized fish scale scaffolds for enhancing tendon-bone healing  

作　　者：Fei Han Tian Li Mengmeng Li Bingjun Zhang Yufeng Wang Yufang Zhu Chengtie Wu 

机构地区：[1]State Key Laboratory of High-Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai,200050,PR China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,100049,PR China [3]Department of Orthopaedic Surgery,Nanjing First Hospital,Nanjing Medical University,Nanjing,210006,PR China

出　　处：《Bioactive Materials》2023年第2期29-40,共12页生物活性材料（英文）

基　　金：supported by the National Basic Research Program of China(grant No.2021YFA0715700);the Natural Science Foundation of China(32130062);Innovation Cross Team of Chinese Academy of Sciences(JCTD-2018-13);Science and Technology Commission of Shanghai Municipality(20442420300,21DZ1205600).

摘　　要：Tendon-bone healing is essential for an effective rotator cuff tendon repair surgery,however,this remains a significant challenge due to the lack of biomaterials with high strength and bioactivity.Inspired by the high-performance exoskeleton of natural organisms,we set out to apply natural fish scale(FS)modified by calcium silicate nanoparticles(CS NPs)as a new biomaterial(CS-FS)to overcome the challenge.Benefit from its“Bouligand”microstructure,such FS-based scaffold maintained excellent tensile strength(125.05 MPa)and toughness(14.16 MJ/m^(3)),which are 1.93 and 2.72 times that of natural tendon respectively,allowing it to well meet the requirements for rotator cuff tendon repair.Additionally,CS-FS showed diverse bioactivities by stimulating the differentiation and phenotypic maintenance of multiple types of cells participated into the composition of tendon-bone junction,(e.g.bone marrow mesenchymal stem cells(BMSCs),chondrocyte,and tendon stem/progenitor cells(TSPCs)).In both rat and rabbit rotator cuff tear(RCT)models,CS-FS played a key role in the tendon-bone interface regeneration and biomechanical function,which may be achieved by activating BMP-2/Smad/Runx2 pathway in BMSCs.Therefore,natural fish scale-based biomaterials are the promising candidate for clinical tendon repair due to their outstanding strength and bioactivity.

关 键 词：Fish scales Tendon repair High strength BIOACTIVITIES Tendon-bone healing enhancement 

分 类 号：R318.08[医药卫生—生物医学工程]