11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展  

Progress on the role of 11β-HSD1 in inflammation,development of hepatocellular carcinoma and immunity

作　　者：雷星煜 冯雪松 晁旭[1,2] LEI Xingyu;FENG Xuesong;CHAO Xu(College of Basic Medicine Sciences,Shaanxi University of Chinese Medicine,Xianyang 712046;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xi an 712000,China)

机构地区：[1]陕西中医药大学基础医学院,陕西咸阳712046 [2]陕西中医药大学第二附属医院,陕西西安712000

出　　处：《基础医学与临床》2023年第5期837-841,共5页Basic and Clinical Medicine

基　　金：陕西省中医药管理局科研项目(2021-zz-JC001);陕西省教育厅一般项目(20JK0588)。

摘　　要：11β-羟基类固醇脱氢酶1(11β-HSD1)在与代谢有关的炎性疾病,以及免疫中可通过调节糖皮质激素(GC)的合成发挥抗炎或促炎作用。11β-HSD1的整体表达和活性可受促炎细胞因子的诱导,这一过程依赖于NF-κB信号通路并由其基因(HSD11B1)P1和P2启动子的利用水平最终决定。此外,11β-HSD1在肝细胞癌中通过降低葡萄糖摄入和糖酵解抑制肝细胞癌的增殖,并通过调节GC的水平参与胸腺中T细胞的发育和血管生成。了解11β-HSD1在炎性疾病、癌的发生发展、免疫中的分子调控机制有利于探究相关疾病的发生发展。The 11β-hydroxysteroid dehydrogenase 1(11β-HSD1)with anti-inflammatory or pro-inflammatory effects in inflammatory diseases is related to metabolism,as well as in the immune response through regulatpn of glucocorticoid(GC)synthesis.The expression and functional activity of 11β-HSD1 are potentially induced by pro-inflammatory cytokines,this process relies on the NF-κB signaling pathway and is ultimately determined by the utilization levels of HSD11B1 P1 and P2 promoters.In addition,11β-HSD1 inhibits the proliferation of hepatocellular carcinoma by reducing glucose intake and glycolysis in hepatocellular carcinoma,and thus plays a role in the development of T cells in thymus and the form of angiogenesis by regulating the level of GC.Understanding the molecular regulatory mechanism of 11β-HSD1 in inflammatory diseases,carcinogenesis,development and immune response is conducive to exploring the occurrence and development of related diseases.

关 键 词：11β-羟基类固醇脱氢酶(11β-HSD1) 炎性反应 癌的发生发展 免疫 

分 类 号：R34[医药卫生—基础医学]