谷氨酸转运蛋白EAAT2参与早产儿脑损伤作用机制研究进展  

Research Progress on the Mechanism of Glutamate Transporter Protein(EAAT2)Involved in Brain Injury in preterm infants

作　　者：崔洁琼 曹婷 陈潜 林子涵 江春融 李华妍 熊磊 CUI Jieqiong;CAO Ting;CHEN Qian;LIN Zihan;JIANG Chunrong;LI Huayan;XIONG Lei(Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学,云南昆明650500

出　　处：《云南中医药大学学报》2023年第1期71-76,共6页Journal of Yunnan University of Chinese Medicine

基　　金：国家自然科学基金(82074421,82160924);全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号);岐黄学者-国家中医药领军人才支持计划(国中医药人教函[2022]6号);云南省教育厅科学研究基金项目(2021Y456);。

摘　　要：早产儿每年约占全世界所有新生儿的11%,有较高的伴发神经精神疾病、发育障碍及终身残疾的风险。谷氨酸(glutamic acid,GLU)作为重要的兴奋性神经递质,对中枢神经系统的功能正常起重要作用。兴奋性氨基酸转运蛋白2(EAAT2)是主要的谷氨酸转运蛋白,负责清除高达95%的细胞外谷氨酸,防止神经元兴奋性毒性和过度兴奋。增强EAAT2表达和转运功能作为成人神经系统疾病的潜在治疗方法备受关注,但在预防早产儿脑损伤中的作用仍有待探索。本文就EAAT2在早产儿脑损伤中的相关机制进行综述,为预防早产儿脑损伤的研究提供新方向。Preterm infants account for approximately 11%of all births worldwide each year and can be associated with a higher risk of neuropsychiatric disorders,developmental disorders,and lifelong disabilities.Glutamic acid(GLU),an important excitatory neurotransmitter,plays an important role in the normal function of the central nervous system.Excitatory amino acid transporter 2(EAAT2)is the major glutamate transporter protein responsible for the removal of up to 95%of extracellular glutamate,preventing neuronal excitotoxicity and hyperexcitability.Enhancement of EAAT2 expression and transporter function has received much attention as a potential treatment for adult neurological disorders,but its role in preventing brain injury in preterm infants remains to be explored.In this paper,we review the mechanisms related to EAAT2 in brain injury in preterm infants to provide a new direction for research on the prevention of brain injury in preterm infants.

关 键 词：早产儿 脑损伤 谷氨酸 兴奋毒性 谷氨酸转运蛋白2 作用机制 研究进展 

分 类 号：R722.6[医药卫生—儿科]