运动诱导的代谢物与脂肪棕色化的调节机制  

Regulatory Mechanisms of Exercise-Induced Metabolites and Adipose Browning

作　　者：李林[1] 曲雅倩 陈敏[1] 陈思宇 孙景权 LI Lin;QU Yaqian;CHEN Min;CHEN Siyu;SUN Jingquan(Sichuan University,Chengdu 610065,China)

机构地区：[1]四川大学,四川成都610065

出　　处：《中国体育科技》2023年第4期50-57,共8页China Sport Science and Technology

基　　金：国家自然科学基金项目(31801002);中央高校基本科研业务费专项资金项目(2021自研-体育006)。

摘　　要：通过检索与分析相关文献,对脂肪棕色化的生物学机制和生理意义,运动锻炼对脂肪棕色化的影响,运动锻炼对代谢物的影响,以及代谢物参与运动诱导脂肪棕色化的可能生物学机制进行综述。研究显示,运动可对循环系统中葡萄糖、丙酮酸和乳酸等糖代谢物,丙氨酸、支链氨基酸等氨基酸代谢物,游离脂肪酸等脂代谢物以及柠檬酸、琥珀酸和α-酮戊二酸等三羧酸循环代谢物水平产生显著影响。其中,琥珀酸、α-酮戊二酸、犬尿喹啉酸、β-氨基异丁酸和乳酸等代谢物参与运动诱导的白色脂肪棕色化。因此,研究认为:1)运动可通过诱导代谢物堆积参与促进脂肪棕色化;2)参与运动促进白色脂肪棕色化进程的代谢物包括琥珀酸、α-酮戊二酸、犬尿喹啉酸、β-氨基异丁酸和乳酸等。This study reviewed the biological mechanism and physiological significance of adipose browning,the effects of exercise on browning,the effects of exercise on metabolites,and the possible biological mechanism of metabolites participating in exercise-induced adipose browning,in order to provide a new direction for studying the biological mechanism of exercise-induced adipose browning.Research shows that:Exercise has significant effects on metabolites of glucose such as pyruvate and lactate,metabolites of amino acid such as alanine and branched chain amino acids,metabolites of lipid such as free fatty acids,and metabolites of tricarboxylic acid cycle such as citrate,succinate andα-ketoglutarate.The metabolites including succinate,α-ketoglutarate,kynurenic acid,β-aminoisobutyric acid and lactate participate in the browning of white adipose induced by exercise.Conclusions:1)Exercise can promote adipose browning by inducing metabolites accumulation;2)metabolites involved in the promotion of exercise-induced adipose browning process include succinate,α-ketoglutarate,kynurenic acid,β-aminoisobutyric acid and lactate and so on.

关 键 词：运动训练 脂肪棕色化 代谢物 解偶联蛋白-1 

分 类 号：G804.7[文化科学—运动人体科学]