Effects of probiotics and its fermented milk on constipation: a systematic review  

作　　者：Jiaming Yan Meiling Wu Wei Zhao Lai-Yu Kwok Wenyi Zhang 

机构地区：[1]Key Laboratory of Dairy Biotechnology and Engineering,Ministry of Education,Inner Mongolia Agricultural University,Hohhot 010018,China [2]Key Laboratory of Dairy Products Processing,Ministry of Agriculture,Inner Mongolia Agricultural University,Hohhot 010018,China

出　　处：《Food Science and Human Wellness》2023年第6期2124-2134,共11页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China(31922071);the Natural Science Foundation of Inner Mongolia Autonomous Region of China(2021ZD08);Science Fund for Distinguished Young Scholars of Inner Mongolia Agricultural University(BR220301).

摘　　要：This study reviewed clinical evidence of probiotics-mediated effects on constipation.Four databases were used in the literature searches,namely Cochrane Library,Embase,Pubmed,and Web of Science.The last retrieval time was March 2021.Collected data were analyzed by Review Manager(version 5.3)and Stata(version 14).The primary search retrieved 8418 articles after removing duplicates.Eventually,26 studies were included in the meta-analysis.Administration of probiotics signifi cantly increased stool frequency(MD:1.15 times/week;95%CI:0.59 to 1.70;P<0.0001),improved bloating(MD:-0.48;95%CI:-0.89 to-0.07;P=0.02),reduced abdominal pain(MD:-0.71;95%CI:-1.25 to-0.16;P=0.01),and improved quality of life(MD:-0.73;95%CI:-1.37 to-0.10;P=0.02).However,the clinical effect of intake of probiotics on stool consistency was non-signifi cant(MD:0.07;95%CI:-0.34 to 0.48;P=0.73).Based on our analysis,probiotic supplements were effective in relieving constipation through symptom improvement.The effectiveness of dosage forms of intervention ranked:capsules>others(tablets,powder)>fermented milk.

关 键 词：CONSTIPATION PROBIOTICS Fermented milk META-ANALYSIS Dosage form 

分 类 号：TS252.54[轻工技术与工程—农产品加工及贮藏工程]