Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice  

作　　者：Jing Li Xinyue Yu Xinxing Xu Peipei Tang Shuang Bi Xiaopu Ren Yong Shi Jihong Wu Fei Lao 

机构地区：[1]National Engineering Research Center for Fruit&Vegetable Processing,Key Laboratory of Fruit&Vegetable Processing,Ministry of Agriculture and Rural Affairs,Beijing Key Laboratory for Food Non-thermal Processing,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China [2]Beijing Daily Chemical Products Quality Supervision and Inspection Station,Beijing 101111,China [3]Department of Food Science and Technology,The Ohio State University,Columbus 43210,USA [4]College of Food Science and Engineering,Tarim University,Alar 843300,China [5]Haoxiangni Health Food Co.,Ltd.,Xinzheng 451100,China

出　　处：《Food Science and Human Wellness》2023年第6期2286-2296,共11页食品科学与人类健康（英文）

基　　金：supported by the Chinese Universities Scientific Fund(2022TC124);open foundation of Beijing Advanced Innovation Center for Food Nutrition and Human Health.

摘　　要：Unfermented jujube pulp(UFJP),fermented jujube pulp(FJP)in high and low doses were fed to constipated ICR mice.Defecation function,serum gastrointestinal regulatory peptide,fecal short-chain fatty acids(SCFAs)and gut microbial composition were assessed.Results showed that high-dose FJP could protect intestinal mucosa tissue,shorten the first black feces defecating time by 17%and increase the number and wet weights of black feces by 72%and 71%,respectively,within 6 h.High-dose FJP signifi cantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice,compared with low-dose FJP and UFJP.The high-dose FJP intervention regulated the microbiota profi le,which afterwards restored microbiota,like Bacteroidetes,Bifi dobacterium and Lactobacillus,to a less unhealthy state.This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.

关 键 词：JUJUBE Lactic acid bacteria fermentation Short-chain fatty acid PROBIOTICS Gut microbiota 

分 类 号：TS255.1[轻工技术与工程—农产品加工及贮藏工程]