叶酸模板法合成中空结构碳酸钙微球及其载药性能探究  

Study on the synthesis of hollow calcium carbonate microsphere by template method using folic acid and its drug loading performance

作　　者：郭紫婷 李威 陈秋娟[2] 莫福旺 GUO Ziting;LI Wei;CHEN Qiujuan;MO Fuwang(School of Materials Science and Engineering,Guilin University of Electronic Technology,Guilin 541004,China;Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization,College of Materials&Chemical Engineering,Hezhou University,Hezhou 542899,China)

机构地区：[1]桂林电子科技大学材料科学与工程学院,广西桂林541004 [2]广西碳酸钙资源综合利用重点实验室,贺州学院材料与化学工程学院,广西贺州542899

出　　处：《功能材料》2023年第4期4110-4114,共5页Journal of Functional Materials

基　　金：广西自然科学基金青年科学基金项目(2018GXNSFBA281200)。

摘　　要：利用水热法,在CaCl_(2)和Na_(2)CO_(3)溶液中分别添加等量叶酸,混合溶液反应后制备了中空碳酸钙微球前驱体,在温度600℃锻烧2 h后得到中空碳酸钙微球。利用XRD、SEM分别对微球的结构和形貌进行了测试,发现微球的粒径分布在5~10μm之间,呈现出中空的微孔结构。将中空微球分别氨基化、羧基化和聚乙烯亚胺包覆改性后,以盐酸阿霉素(DOX)为模型药物进行载药实验,发现DOX的药物负载率达到349.81 mg/g,在还原型谷胱甘肽溶液中,药物载体在0~12 h内能够持续缓慢释放,在肿瘤微环境浓度比较低的时候释放量比较大,最高的释放率可以达到1.34%,12 h后释放率为0.63%。前4 h内药物释放比较快,在肿瘤水平不高的情形下可以实现缓慢释药。Hollow calcium carbonate(precursor)were synthesized via a hydro-thermal method with additive of folic acid in PTFE reactor kettle.Hollow calcium carbonate were obtained upon calcination at temperature of 600℃over two hours.The phase structure,morphology were characterized by X-ray diffraction and scan electron microscopy.The results show that particle size was between 5 and 10μm and showed a hollow microporous structure.The as-prepared samples were a minylated,carboxylated and polythlenimine coated and modified before drug loaded with doxorubicin hydrochloride(DOX).It was found that the drug load rate of DOX reached 349.81 mg/g.In the prototype glutathione solution,the drug carrier could continuously release slowly within 0-12 h.When the tumor microenvironment concentration was relatively low,the highest release rate reached 1.34%,and the release rate was 0.63%after 12 hours.Generally,the drug release is relatively fast within the first 4 hours,and the slow release can be achieved if the tumor level is not high.

关 键 词：中空碳酸钙 叶酸 盐酸阿霉素 载药 缓释 

分 类 号：TB34[一般工业技术—材料科学与工程]