富血小板血浆治疗椎间盘退变的机制及临床应用  

Mechanism and Clinical Application of Platelet-Rich Plasma in the Treatment of Intervertebral Disc Disease

作　　者：杨焕莹 王想福[2] 赵道洲[2] 叶丙霖[2] 李晨旭[2] 石瑞芳[2] YANG Huanying;WANG Xiangfu;ZHAO Daozhou;YE Binglin;LI Chenxu;SHI Ruifang(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of TCM,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中医院,兰州730050

出　　处：《中国细胞生物学学报》2023年第2期240-246,共7页Chinese Journal of Cell Biology

基　　金：兰州市科技发展计划(批准号:2020-ZD-36);兰州市人才创新创业项目(批准号:2020-RC-54);甘肃省自然科学基金(批准号:21JR1RA058)资助的课题。

摘　　要：椎间盘退变(intervertebral disc disease,IVDD)具有高发病率、高致残率等特点,在全球范围内流行,是当前严重危害人类生命健康的重大疾病之一。传统治疗包括卧床休息、物理治疗、抗炎止痛药物和手术,但都仅能起到缓解患者临床症状的作用,尚不能延缓或逆转IVDD的发展进程。富血小板血浆(platelet-rich plasma,PRP)是多种生长因子的天然载体,近年来的研究提示,它具有抑制炎症反应,抑制细胞凋亡、促进细胞增殖,增加细胞外基质等三方面的作用,可作为IVDD的有效治疗方法。该文主要阐述PRP作为一种再生疗法在IVDD中的治疗机制,并讨论其临床应用的研究进展。IVDD(intervertebral disc disease)has the characteristics of high incidence and high disability rate.It is popular worldwide and is one of the major diseases that seriously endanger human life and health at present.Traditional treatments,including bed rest,physical therapy,anti-inflammatory analgesics,and surgery,have only been able to relieve the patient’s clinical symptoms,but have not been able to delay or reverse the progression of IVDD.PRP(platelet-rich plasma)is a natural carrier of various growth factors.Recent studies suggest that it can inhibit inflammation,inhibit cell apoptosis,promote cell proliferation and increase extracellular matrix,and can be used as an effective treatment for IVDD.This article mainly describes the mechanism of PRP as a regenerative therapy in the treatment of IVDD,and discusses its clinical application research progress.

关 键 词：椎间盘退变 富血小板血浆 生物疗法 生长因子 

分 类 号：R681.53[医药卫生—骨科学]