IgA肾病与肠黏膜免疫系统异常相关性及治疗进展  

Correlation between IgA nephropathy and abnormal intestinal mucosal immune system and its treatment progress

作　　者：杨凯(综述)[1] 魏佳莉(审校)[1] YANG Kai;WEI Jiali(Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University,Haikou,Hainan 570000,China)

机构地区：[1]海南省人民医院/海南医学院附属海南医院,海南海口570000

出　　处：《现代医药卫生》2023年第8期1375-1379,共5页Journal of Modern Medicine & Health

基　　金：国家自然科学基金项目(82160135)。

摘　　要：免疫球蛋白A(IgA)肾病是最常见的导致终末期肾病的原发性肾小球疾病,病因和发病机制尚不清楚,且由于该病临床和病理表现的多样性,尚无统一的治疗方案。目前,肠道黏膜免疫异常假说,也就是四重打击说被广泛认为与IgA肾病发病相关,靶向治疗成为未来治疗方向。Immunoglobulin A(IgA)nephropathy is the most common primary glomerular disease leading to end-stage renal disease.The etiology and pathogenesis are still unknown,and due to the diversity of clinical and pathological manifestations of the disease,there is no unified treatment plan for the disease.At present,the hypothesis of intestinal mucosal immunity abnormality,that is the four-hits theory,is widely considered to be related to the pathogenesis of IgA nephropathy,and targeted therapy has become the future treatment direction.

关 键 词：免疫球蛋白A肾病 肠黏膜免疫 肠黏膜靶向激素 靶向治疗 综述 

分 类 号：R593.9[医药卫生—内科学] R459.9[医药卫生—临床医学]