髓源性抑制细胞研究进展  

Advance in myeloid-derived suppressor cells

作　　者：孙健[1,2] 张继明 SUN Jian;ZHANG Jiming(Department of Infectious Diseases,Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response,National Medical Center for Infectious Diseases,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Infectious Diseases,the First Affiliated Hospital of Wannan Medical College,Wuhu 241000;Key Laboratory of Medical Molecular Virology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Department of Infectious Diseases,Jing’an Branch of Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040 [2]皖南医学院第一附属医院感染科,芜湖241000 [3]复旦大学上海医学院医学分子病毒学重点实验室,上海200032 [4]复旦大学附属静安区中心医院感染科,上海200040

出　　处：《微生物与感染》2022年第6期386-394,共9页Journal of Microbes and Infections

基　　金：国家自然科学基金项目(81871640,81670528);上海市临床重点专科建设项目(ZK2019B24);上海申康医院发展中心临床科技创新项目(SHDC 12019116)。

摘　　要：髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)是一群表型异常、具有免疫抑制功能的髓系来源细胞。在进展期肿瘤、败血症、慢性感染等病理环境中,MDSCs大量扩增并通过多种途径抑制T淋巴细胞等免疫细胞的增殖、活化和迁移,MDSCs的数量与疾病进程和患者转归密切相关。通过单细胞测序、质谱流式等新技术,研究人员发现MDSCs和正常髓系细胞在表型标记分子、基因表达、能量代谢和调控通路上存在明显差异。特别是在肿瘤领域,MDSCs靶向治疗研究也取得了丰硕的成果。本文以MDSCs研究里程碑为起点,以MDSCs靶向治疗机制及其在感染性疾病中的作用为重点,对MDSCs新近研究成果进行综述。Myeloid-derived suppressor cells(MDSCs)are a population of myeloid-derived cells with specific markers and immunosuppressive functions.MDSCs can enrich under pathological conditions(e.g.,advanced cancer,sepsis,and chronic infection)and suppress the proliferation,activation,and migration of T lymphocytes and other immune cells.The frequencies of MDSCs are significantly associated with disease development and patient outcomes.Through new detection methods including single cell sequencing and mass spectrometry,researchers have found significant differences in phenotypic markers,genetic expression,metabolism,and regulatory pathways between MDSCs and normal myeloid cells.Abundant achievements have been also obtained on therapies targeting MDSCs especially in cancer research.In this review,we start with milestones in MDSCs research,focus on the mechanisms of therapies targeting MDSCs and their roles in infectious diseases,and summarize recent achievements in MDSCs research.

关 键 词：髓源性抑制细胞 基因表达 代谢 感染 乙型肝炎病毒 

分 类 号：R392.1[医药卫生—免疫学]