药物涂层球囊在自体动静脉瘘狭窄治疗中的应用  

Application of drug⁃coated balloon in treatment of arteriovenous fistula stenosis

作　　者：李越 王兵[1] 牛晓阳[1] 刘文江 高士钦 丁亚坤 LI Yue;WANG Bing;NIU Xiaoyang;LIU Wenjiang;GAO Shiqin;DING Yakun(Department of Vascular Surgery,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第五附属医院血管外科,郑州450052

出　　处：《实用医学杂志》2023年第6期724-729,共6页The Journal of Practical Medicine

基　　金：河南省医学科技攻关计划省部共建基金资助项目(编号:2018010012)。

摘　　要：目的评估药物涂层球囊(drug coated balloon,DCB)治疗自体动静脉瘘狭窄的中短期临床效果。方法回顾性分析2020年5月至2021年12月腔内治疗43例自体动静脉瘘狭窄患者的临床资料,22例行药物涂层球囊治疗(DCB组),21例行普通球囊治疗(PAB组),术后对比两组3、6、12个月靶病变一期通畅率(TLPP)、循环通路一期通畅率(ACPP)、晚期管腔丢失(LLL)等指标。结果所有病例手术均获成功,术后3个月两组TLPP差异无统计学意义,术后6、12个月DCB组的TLPP较PAB组明显提高[(81.8%vs.47.6%)、(54.5%vs.23.8%),均P<0.05],术后3、6、12个月两组的ACPP差异无统计学意义;术后DCB组6、12个月LLL明显低于PAB组(P<0.05)。结论药物涂层球囊治疗自体动静脉瘘的中短期临床效果较好,对比普通球囊优势显著。Objective To evaluate the short⁃and medium⁃term efficacy of drug⁃coated balloon(DCB)in the treatment of arteriovenous fistula stenosis.Methods The clinical data of 43 patients with arteriovenous fistula stenosis treated with endovascular therapy from May 2020 to December 2021 were retrospectively analyzed.Twenty⁃two patients were treated with DCB(DCB group),and 21 patients with plain angioplasty balloon(PAB group).Target lesion primary patency(TLPP),access circuit primary patency(ACPP),late lumen loss(LLL)and other indicators were compared between the two groups at 3,6,12 months after operation.Results The operation was successful in all cases.There was no significant difference in TLPP between the two groups 3 months after opera⁃tion.The TLPP of DCB group was significantly higher than that of PAB group 6 and 12 months after operation[(81.8%vs.47.6%),(54.5%vs.23.8%),both (P<0.05)];there was no significant difference in ACPP between the two groups 3,6,12 months after operation;LLL 6 and 12 months after operation in DCB group was significant⁃ly lower than that in PAB group(P<0.05).Conclusion DCB has a better clinical efficacy and significant advan⁃tage over plain angioplasty balloon in the treatment of arteriovenous fistula.

关 键 词：血液透析 自体动静脉瘘狭窄 经皮腔内血管成形术 药物涂层球囊 

分 类 号：R654.4[医药卫生—外科学]