从湿辨治抗血管内皮生长因子治疗后视网膜静脉阻塞黄斑水肿的疗效观察  

Observation on the therapeutic effect of anti VEGF therapy on macular edema after retinal vein occlusion based on syndrome differentiation and treatment from dampness

作　　者：欧扬 王逸之 林斌武 庞龙 OU Yang;WANG Yizhi;LIN Binwu;PANG Long(The Second Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广州中医药大学第二附属医院,广州510120 [2]上海中医药大学附属龙华医院,上海200032

出　　处：《实用医学杂志》2023年第6期762-767,共6页The Journal of Practical Medicine

基　　金：国家自然科学基金面上项目(编号:82074499)。

摘　　要：目的 客观评价真实世界下抗血管内皮生长因子(VEGF)治疗联合从湿辨治对视网膜静脉阻塞黄斑水肿形态学的影响。方法 真实世界研究,纳入2020年7月至2021年12月在医院就诊的湿证型视网膜静脉阻塞黄斑水肿患者,分为观察组(从湿辨治联合抗VEGF治疗)和对照组(单纯抗VEGF治疗)。治疗3个月后,观察治疗前后黄斑中心凹视网膜厚度(CMT)、视网膜内液高度(IRF)、视网膜下液高度(SRF)。结果 观察组CMT、IRF、SRF均较治疗前降低,对照组CMT、IRF、SRF均较治疗前降低,随访3个月,观察组CMT、IRF较对照组更低,差异有统计学意义(P <0.05)。结论 抗VEGF治疗后联合从湿辨治较单纯抗VEGF治疗能更有效改善湿证型视网膜静脉黄斑水肿的形态学表现,尤其能更明显的减少视网膜内液。Objective To objectively evaluate the effect of anti vascular endothelial growth factor(VEGF)therapy combined withdifferentiation and treatment from dampness on the morphology of macular edema in retinal vein occlusion(RVO)in the real world.Methods The real world study included the patients with macular edema due to retinal vein occlusion of dampness syndrome who were treated in hospital from July 2020 to December 2021.They were divided into the observation group(differentiation and treatment from dampness combined with anti VEGF treatment)and the control group(anti VEGF treatment).After 3 months of treatment,the retinal thick⁃ness(CMT),intraretinal fluid(IRF)height and subretinal fluid(SRF)height of macular fovea were observed before and after treatment.Results CMT,IRF and SRF in the observation group were lower than those before treatment,while CMT,IRF and SRF in the control group were lower than those before treatment.After 3 months of follow⁃up,CMT and IRF in the observation group were lower than those in the control group,with a statistical difference(P<0.05).Conclusion The combination of anti VEGF therapy and differentiation and treatment from dampness can effectively improve the morphology of retinal vein macular edema of dampness syndrome,especially reduce the retinal fluid more significantly.

关 键 词：视网膜静脉阻塞 黄斑水肿 视网膜内液 视网膜下液 湿证 血管内皮生长因子 

分 类 号：R276.7[医药卫生—中医五官科学]