Smart dental materials for antimicrobial applications  

作　　者：Carolina Montoya Lina Roldan Michelle Yu Sara Valliani Christina Ta Maobin Yang Santiago Orrego 

机构地区：[1]Department of Oral Health Sciences,Kornberg School of Dentistry,Temple University,Philadelphia,PA,USA [2]Bioengineering Research Group(GIB),Universidad EAFIT,Medellín,Colombia [3]Department of Endodontology,Kornberg School of Dentistry,Temple University,Philadelphia,PA,USA [4]Bioengineering Department,College of Engineering,Temple University,Philadelphia,PA,USA

出　　处：《Bioactive Materials》2023年第6期1-19,共19页生物活性材料（英文）

摘　　要：Smart biomaterials can sense and react to physiological or external environmental stimuli(e.g.,mechanical,chemical,electrical,or magnetic signals).The last decades have seen exponential growth in the use and development of smart dental biomaterials for antimicrobial applications in dentistry.These biomaterial systems offer improved efficacy and controllable bio-functionalities to prevent infections and extend the longevity of dental devices.This review article presents the current state-of-the-art of design,evaluation,advantages,and limitations of bioactive and stimuli-responsive and autonomous dental materials for antimicrobial applications.First,the importance and classification of smart biomaterials are discussed.Second,the categories of bioresponsive antibacterial dental materials are systematically itemized based on different stimuli,including pH,enzymes,light,magnetic field,and vibrations.For each category,their antimicrobial mechanism,applications,and examples are discussed.Finally,we examined the limitations and obstacles required to develop clinically relevant applications of these appealing technologies.

关 键 词：ANTIMICROBIAL Antibacterial ANTIFUNGAL Smart dental materials Bioresponsive biomaterials STIMULI-RESPONSIVE Restorative dentistry BIOFILM ANTIBIOFILM Bioactive 

分 类 号：TB34[一般工业技术—材料科学与工程]