Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing  

作　　者：Nanbo Liu Shuoji Zhu Yuzhi Deng Ming Xie Mingyi Zhao Tucheng Sun Changjiang Yu Ying Zhong Rui Guo Keluo Cheng Dehua Chang Ping Zhu 

机构地区：[1]Guangdong Cardiovascular Institute,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong,510100,China [2]University of Tokyo Hospital Department of Cell Therapy in Regenerative Medicine,Tokyo,113-8666,Japan [3]University of Tokyo,Tokyo,113-8666,Japan [4]Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong,524001,China [5]Key Laboratory of Biomaterials of Guangdong Higher Education Institutes,Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development,Department of Biomedical Engineering,Jinan University,Guangzhou,510632,China [6]Guangdong Provincial Key Laboratory of Pathogenesis,Targeted Prevention and Treatment of Heart Disease,Guangzhou Key Laboratory of Pathogenesis,Targeted Prevention and Treatment of Heart Disease,Guangzhou,Guangdong,510100,China

出　　处：《Bioactive Materials》2023年第6期69-80,共12页生物活性材料（英文）

基　　金：funded by National Key Research and Development Program of China(2017YFA0105602,2018YFA0108700);NSFC Projects of INTERNATIONAL COOPERATION and Exchanges(81720108004);National Natural Science Foundation of China(81974019,82100275);Guangdong Provincial Special Support Program for Prominent Talents(2021JC06Y656);Science and Technology Planning Project of Guangdong Province(2020B1111170011,2022B1212010010);Guangdong special funds for science and technology innovation strategy,China(Stability support for scientific research institutions affiliated to Guangdong Province-GDCI 2021);Guangzhou Science and Technology Plan Project(202201000006);The Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital(DFJH201812,KJ012019119,KJ012019423);The Marine Economy Development Project of Department of Natural Resources of Guangdong Province(No.GDNRC[2022]039).

摘　　要：Damaged skin cannot prevent harmful bacteria from invading tissues,causing infected wounds or even severe tissue damage.In this study,we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate(Cu-EGCG)nano-capsules.The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus).It could also promote the proliferation and migration of L929 fibroblasts.In vivo full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect.Accelerate collagen deposition and wound healing speed were also observed in the SilMA/HAMA/Cu-EGCG hydrogel treated group.The findings of this study show the great potential of this controlled-release antibacterial composite hydrogel in the application of chronic wound healing.

关 键 词：Metal polyphenol network Copper Epigallocatechin-3-gallate Infected wound healing 

分 类 号：TB3[一般工业技术—材料科学与工程]