Nanomaterial-assisted theranosis of bone diseases  

作　　者：Kai Zheng Jiaxiang Bai Huilin Yang Yaozeng Xu Guoqing Pan Huaiyu Wang Dechun Geng 

机构地区：[1]Department of Orthopedics,The First Affiliated Hospital of Soochow University,188 Shizi Road,Suzhou,215006,Jiangsu,China [2]Center for Human Tissues and Organs Degeneration,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China [3]Institute for Advanced Materials,School of Materials Science and Engineering,Jiangsu University,Zhenjiang,212013,Jiangsu,China

出　　处：《Bioactive Materials》2023年第6期263-312,共50页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(82072425,82072498,81871788,21875092,31922040,82272157);the Natural Science Foundation of Jiangsu Province(BK2021650 and BK20220059);the“Jiangsu Specially-Appointed Professor”Program;the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Jiangsu Medical Research Project(ZD2022021);Special Project of Diagnosis;Treatment Technology for Key Clinical Diseases in Suzhou(LCZX202003);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_3217).

摘　　要：Bone-related diseases refer to a group of skeletal disorders that are characterized by bone and cartilage destruction.Conventional approaches can regulate bone homeostasis to a certain extent.However,these therapies are still associated with some undesirable problems.Fortunately,recent advances in nanomaterials have provided unprecedented opportunities for diagnosis and therapy of bone-related diseases.This review provides a comprehensive and up-to-date overview of current advanced theranostic nanomaterials in bone-related diseases.First,the potential utility of nanomaterials for biological imaging and biomarker detection is illustrated.Second,nanomaterials serve as therapeutic delivery platforms with special functions for bone homeostasis regulation and cellular modulation are highlighted.Finally,perspectives in this field are offered,including current key bottlenecks and future directions,which may be helpful for exploiting nanomaterials with novel properties and unique functions.This review will provide scientific guidance to enhance the development of advanced nanomaterials for the diagnosis and therapy of bone-related diseases.

关 键 词：NANOMATERIALS Delivery DIAGNOSIS THERAPY Bone-related diseases 

分 类 号：R318.08[医药卫生—生物医学工程]