Systematic in vitro and in vivo study on biodegradable binary Zn-0.2 at%Rare Earth alloys(Zn-RE:Sc,Y,La-Nd,Sm-Lu)  

作　　者：Shaokang Du Yunong Shen Yufeng Zheng Yan Cheng Xiaoxue Xu Dafu Chen Dandan Xia 

机构地区：[1]Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,100871,China [2]School of Materials Science and Engineering,Peking University,Beijing,100871,China [3]School of Biomedical Engineering,Faculty of Engineering and Information Technology,University of Technology Sydney,NSW,2007,Australia [4]Laboratory of Bone Tissue Engineering,Beijing Laboratory of Biomedical Materials,Beijing Research Institute of Traumatology and Orthopaedics,Beijing Jishuitan Hospital,Beijing,100035,China [5]Department of Dental Materials,Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing 100081,China

出　　处：《Bioactive Materials》2023年第6期507-523,共17页生物活性材料（英文）

基　　金：supported by the National Key R&D Program of China[2018YFE0104200];the National Natural Science Foundation of China[51931001,52171233,52271243,U22A20121];the INTERNATIONAL COOPERATION and Exchange project of NSFC-RFBR[52111530042];the Beijing Natural Science Foundation[L212014];the Beijing Nova Program.

摘　　要：Biomedical implants and devices for tissue engineering in clinics,mainly made of polymers and stiff metallic materials,require possibly secondary surgery or life-long medicine.Biodegradable metals for biomedical implants and devices exhibit huge potential to improve the prognosis of patients.In this work,we developed a new type of biodegradable binary zinc(Zn)alloys with 16 rare earth elements(REEs)including Sc,Y,La to Nd,and Sm to Lu,respectively.The effects of REEs on the alloy microstructure,mechanical properties,corrosion behavior and in vitro and in vivo biocompatibility of Zn were systematically investigated using pure Zn as control.All Zn-RE alloys generally exhibited improved mechanical properties,and biocompatibilities compared to pure Zn,especially the tensile strength and ductility of Zn-RE alloys were dramatically enhanced.Among the Zn-RE alloys,different REEs presented enhancement effects at varied extent.Y,Ho and Lu were the three elements displaying greatest improvements in majority of alloys properties,while Eu,Gd and Dy exhibited least improvement.Furthermore,the Zn-RE alloys were comparable with other Zn alloys and also exhibited superior properties to Mg-RE alloys.The in vivo experiment using Zn-La,Zn-Ce,and Zn-Nd alloys as tibia bone implants in rabbit demonstrated the excellent tissue biocompatibility and much more obvious osseointegration than the pure Zn control group.This work presented the significant potential of the developed Zn-RE binary alloys as novel degradable metal for biomedical implants and devices.

关 键 词：Biodegradable metals Zn-Rare Earth alloys Mechanical property Biodegradation behavior BIOCOMPATIBILITY 

分 类 号：TG146.2[一般工业技术—材料科学与工程]