Infection-responsive long-term antibacterial bone plates for open fracture therapy  

作　　者：Lujiao Zhang Yurun Yang Yan-Hua Xiong Yu-Qing Zhao Zongpeng Xiu Hui-Min Ren Kai Zhang Shun Duan Ying Chen Fu-Jian Xu 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology),Ministry of Education,Beijing Laboratory of Biomedical Materials,Beijing Advanced Innovation Center for Soft Matter Science and Engineering,Beijing University of Chemical Technology,Beijing,100029,China [2]Department of Orthopaedic Surgery,China-Japan Friendship Hospital,Beijing,100029,China

出　　处：《Bioactive Materials》2023年第7期1-12,共12页生物活性材料（英文）

基　　金：This work was supported by National Natural Science Foundation of China[Grant Nos.52122304,52073024 and 51873012];Beijing Outstanding Young Scientist Program[Grant No.BJJWZYJH01201910010024];Chinese Association of Rehabilitation Medicine Technology Development Project[Grant No.KFKT-2022-002].

摘　　要：The infections in open fracture induce high morbidity worldwide.Thus,developing efficient anti-infective orthopedic devices is of great significance.In this work,we designed a kind of infection-responsive long-term antibacterial bone plates.Through a facile and flexible volatilization method,a multi-aldehyde polysaccharide derivative,oxidized sodium alginate,was crosslinked with multi-amino compounds,gentamycin and gelatin,to fabricate a uniform coating on Ti bone plates via Schiff base reaction,which was followed by a secondary crosslinking process by glutaraldehyde.The double-crosslinked coating was stable under normal condition,and could responsively release gentamycin by the triggering of the acidic microenvironment caused by bacterial metabolism,owning to the pH-responsiveness of imine structure.The thickness of the coating was ranging from 22.0μm to 63.6μm.The coated bone plates(Ti-GOGs)showed infection-triggered antibacterial properties(>99%)and high biocompatibility.After being soaked for five months,it still possessed efficient antibacterial ability,showing its sustainable antibacterial performance.The in vivo anti-infection ability was demonstrated by an animal model of infection after fracture fixation(IAFF).At the early stage of IAFF,Ti-GOGs could inhibit the bacterial infection(>99%).Subsequently,Ti-GOGs could promote recovery of fracture of IAFF.This work provides a convenient and universal strategy for fabrication of various antibacterial orthopedic devices,which is promising to prevent and treat IAFF.

关 键 词：ANTIBACTERIAL Open fracture Infection-responsive COATING Orthopedic medical device 

分 类 号：R318[医药卫生—生物医学工程]