Bone/cartilage organoid on-chip:Construction strategy and application  

作　　者：Yan Hu Hao Zhang Sicheng Wang Liehu Cao Fengjin Zhou Yingying Jing Jiacan Su 

机构地区：[1]Institute of Translational Medicine,Shanghai University,Shanghai,200444,China [2]Department of Orthopaedics,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,200092,China [3]Musculoskeletal Organoid Research Center,Shanghai University,Shanghai,200444,China [4]Shaoxing Institute of Technology at Shanghai University,Shaoxing,312000,China [5]Department of Orthopaedics,Shanghai Zhongye Hospital,Shanghai,201941,China [6]Department of Orthopaedics,Shanghai Baoshan Luodian Hospital,Shanghai,201908,China [7]Department of Orthopaedics,Honghui Hospital,Xi’an Jiao Tong University,Xi’an,710000,China

出　　处：《Bioactive Materials》2023年第7期29-41,共13页生物活性材料（英文）

基　　金：This work was supported by grants from National Natural Science Foundation of China(No.82230071,92249303 and 82172098 to J.Su);Shanghai Committee of Science and Technology(Laboratory Animal Research Project to J.Su);Shanghai Baoshan District Medical Health Project(No.21-E-14 to L.Cao);China Postdoctoral Science Foundation(No.2022M722033 to Y.Hu).

摘　　要：The necessity of disease models for bone/cartilage related disorders is well-recognized,but the barrier between ex-vivo cell culture,animal models and the real human body has been pending for decades.The organoid-on-a-chip technique showed opportunity to revolutionize basic research and drug screening for diseases like osteoporosis and arthritis.The bone/cartilage organoid on-chip(BCoC)system is a novel platform of multi-tissue which faithfully emulate the essential elements,biologic functions and pathophysiological response under real circumstances.In this review,we propose the concept of BCoC platform,summarize the basic modules and current efforts to orchestrate them on a single microfluidic system.Current disease models,unsolved problems and future challenging are also discussed,the aim should be a deeper understanding of diseases,and ultimate realization of generic ex-vivo tools for further therapeutic strategies of pathological conditions.

关 键 词：Organoid On-chip platform Osteochondral unit Ex-vivo disease model 

分 类 号：R318[医药卫生—生物医学工程]