A“built-up”composite film with synergistic functionalities on Mg-2Zn-1Mn bioresorbable stents improves corrosion control effects and biocompatibility  

作　　者：Zhenglong Dou Shuiling Chen Jiacheng Wang Li Xia Manfred F.Maitz Qiufen Tu Wentai Zhang Zhilu Yang Nan Huang 

机构地区：[1]Key Lab of Advanced Technology of Materials of Education Ministry,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610031,China [2]Affiliated Dongguan Hospital,Southern Medical University,Dongguan,Guangdong,523059,China [3]Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation,Guangzhou,Guangdong,510080,China [4]Department of Cardiology,Third People’s Hospital of Chengdu Affiliated to Southwest Jiaotong University,Chengdu,610031,China [5]Max Bergmann Center of Biomaterials Dresden,Leibniz Institute of Polymer Research Dresden,Hohe Strasse 6,01069,Dresden,Germany

出　　处：《Bioactive Materials》2023年第7期223-238,共16页生物活性材料（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Project 32171326,82072072,81330031);the INTERNATIONAL COOPERATION Project by Science and Technology Department of Sichuan Province(2021YslnFH0056);the High-level Talents Research and Development Program of Affiliated Dongguan Hospital(K202102).

摘　　要：Control of premature corrosion of magnesium(Mg)alloy bioresorbable stents(BRS)is frequently achieved by the addition of rare earth elements.However,limited long-term experience with these elements causes concerns for clinical application and alternative methods of corrosion control are sought after.Herein,we report a“built-up”composite film consisting of a bottom layer of MgF2 conversion coating,a sandwich layer of a poly(1,3-trimethylene carbonate)(PTMC)and 3-aminopropyl triethoxysilane(APTES)co-spray coating(PA)and on top a layer of poly(lactic-co-glycolic acid)(PLGA)ultrasonic spray coating to decorate the rare earth element-free Mg-2Zn-1Mn(ZM21)BRS for tailoring both corrosion resistance and biological functions.The developed“built-up”composite film shows synergistic functionalities,allowing the compression and expansion of the coated ZM21 BRS on an angioplasty balloon without cracking or peeling.Of special importance is that the synergistic corrosion control effects of the“built-up”composite film allow for maintaining the mechanical integrity of stents for up to 3 months,where complete biodegradation and no foreign matter residue were observed about half a year after implantation in rabbit iliac arteries.Moreover,the functionalized ZM21 BRS accomplished re-endothelialization within one month.

关 键 词：Magnesium alloys Bioresorbable stents Composite coating Corrosion control BIOCOMPATIBILITY 

分 类 号：TG174.4[金属学及工艺—金属表面处理]