Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair  

作　　者：Yidan Wang Meng luo Ting Li Chenxi Xie Sihua Li Bo Lei 

机构地区：[1]Frontier Institute of Science and Technology,Xi’an Jiaotong University,Xi’an,710054,China [2]Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University,Xi’an,710054,China [3]State Key Laboratory for Mechanical Behavior of Materials,Xi’an Jiaotong University,Xi’an,710054,China [4]Instrument Analysis Center,Xi’an Jiaotong University,Xi’an,710054,China

出　　处：《Bioactive Materials》2023年第7期319-332,共14页生物活性材料（英文）

基　　金：This work was supported by the Special Support Program for High Level Talents of Shaanxi Province of China,the key R&D plan of Shaanxi Province of China(grant No.2021GXLH-Z-052);State Key Laboratory for Manufacturing Systems Engineering of China(grant No.sklms2021006);Young Talent Support Plan of Xi’an Jiaotong University of China(grant No.QY6J003).

摘　　要：Current treatments for full-thickness skin injuries are still unsatisfactory due to the lack of hierarchically stimulated dressings that can integrate the rapid hemostasis,inflammation regulation,and skin tissue remodeling into the one system instead of single-stage boosting.In this work,a multilayer-structured bioactive glass nanopowder(BGN@PTE)is developed by coating the poly-tannic acid andε-polylysine onto the BGN via facile layer-by-layer assembly as an integrative and multilevel dressing for the sequential management of wounds.In comparison to BGN and poly-tannic acid coated BGN,BGN@PTE exhibited the better hemostatic performance because of its multiple dependent approaches to induce the platelet adhesion/activation,red blood cells(RBCs)aggregation and fibrin network formation.Simultaneously,the bioactive ions from BGN facilitate the regulation of the inflammatory response while the poly-tannic acid and antibacterialε-polylysine prevent the wound infection,promoting the wound healing during the inflammatory stage.In addition,BGN@PTE can serve as a reactive oxygen species scavenger,alleviate the oxidation stress in wound injury,induce the cell migration and angiogenesis,and promote the proliferation stage of wound repair.Therefore,BGN@PTE demonstrated the significantly higher wound repair capacity than the commercial bioglass dressing Dermlin™.This multifunctional BGN@PTE is a potentially valuable dressing for full-thickness wound management and may be expected to extend to the other wounds therapy.

关 键 词：Bioactive materials BIOCERAMICS Bioactive glass nanoparticles Wound repair 

分 类 号：TB3[一般工业技术—材料科学与工程]