复方润燥止痒乳膏治疗老年性皮肤瘙痒症的临床效果  

Clinical effect of compound moistening dryness antipruritic cream in the treatment of senile pruritus

作　　者：龙雄初[1] 龙枚飞[1] 刘小虎 王敏妨 周晓青[3] 孙晓娟[1] 张玉平[4] 赵社海 LONG Xiongchu;LONG Meifei;LIU Xiaohu;WANG Minfang;ZHOU Xiaoqing;SUN Xiaojuan;ZHANG Yuping;ZHAO Shehai(the Hospital of 81st Group Army PLA,Zhangjiakou 075000;Zhangjiakou Hospital of Traditional Chinese Medicine,Zhangjiakou 075000;Wentang Workers Nursing Home,Hebei Federation of Trade Unions,Shijiazhuang 050402;Hebei North University,Zhangjiakou 075000;Mingdebei Community Health Service Center,Qiaoxi District,Zhangjiakou 075000,China)

机构地区：[1]中国人民解放军陆军第八十一集团军医院,河北张家口075000 [2]张家口市中医院,河北张家口075000 [3]河北省总工会温塘工人疗养院,河北石家庄050402 [4]河北北方学院,河北张家口075000 [5]张家口市桥西区明德北社区卫生服务中心,河北张家口075000

出　　处：《临床医学研究与实践》2023年第12期81-84,共4页Clinical Research and Practice

摘　　要：目的探讨复方润燥止痒乳膏治疗老年性皮肤瘙痒症的临床效果。方法选取2021年5月1日至2022年5月31日我院老年科和皮肤科门诊收治的100例老年性皮肤瘙痒症患者作为研究对象,按随机数字表法将其分为治疗组与对照组,各50例。在一般干预的基础上,治疗组采用复方润燥止痒乳膏外涂患处治疗,对照组采用10%尿素乳膏外涂患处治疗。比较两组患者治疗前及治疗2、4周后的瘙痒程度评分;比较两组患者的临床疗效;比较两组患者的不良反应发生情况。结果治疗组48例完成全程治疗和随访,1例失访,1例中途退出。对照组46例完成全程治疗和随访,2例因瘙痒控制不佳改用其他治疗药物,1例失访,1例不配合治疗退出。治疗前,两组的瘙痒程度评分比较,差异无统计学意义(P>0.05);治疗2、4周后,治疗组的瘙痒程度评分低于对照组,差异具有统计学意义(P<0.05)。治疗组的治疗总有效率为81.25%,对照组的治疗总有效率为47.83%,治疗组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗组有2例出现皮肤烧灼感,1例出现红斑,不良反应总发生率为6.25%(3/48);对照组有1例出现皮肤烧灼感,1例出现红肿,不良反应总发生率为4.35%(2/46),两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。两组的不良反应均不严重,未给予特殊处理,停药后好转。结论复方润燥止痒乳膏治疗老年性皮肤瘙痒症患者的临床效果显著,不良反应少,值得临床推广应用。Objective To explore the clinical effect of compound moistening dryness antipruritic cream in the treatment of senile pruritus.Methods From May 1,2021 to May 31,2022,100 senile pruritus patients admitted in the geriatrics and dermatology clinics of our hospital were selected as the research objects.The patients were divided into treatment group and control group according to the random number table method,with 50 cases in each group.On the basis of general intervention,the treatment group was treated with compound moistening dryness antipruritic cream,and the control group was treated with 10%urea cream.The pruritus score of patients of the two groups before treatment and after 2 and 4 weeks of treatment were compared;the clinical efficacy of the two groups of patients was compared;the occurrence of adverse reactions of patients of the two groups was compared.Results In the treatment group,48 cases completed the whole course of treatment and follow-up,1 case lost to follow-up,and 1 case withdrew midway.In the control group,46 patients completed the whole course of treatment and follow-up,2 cases changed to other treatment drugs due to poor itching control,1 case lost to follow-up,and 1 case withdrew from the treatment.Before treatment,there was no significant difference in pruritus score between the two groups(P>0.05);after 2 and 4 weeks of treatment,the pruritus score of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the treatment group was 81.25%,and that in the control group was 47.83%.The total effective rate of treatment in the treatment group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).In the treatment group,2 cases had skin burning sensation,1 case had erythema,and the total incidence of adverse reactions was 6.25%(3/48).In the control group,1 case had skin burning sensation,1 case had redness and swelling,and the total incidenc

关 键 词：复方润燥止痒乳膏 老年性皮肤瘙痒症 尿素乳膏 

分 类 号：R758.31[医药卫生—皮肤病学与性病学]