中药改善高血压左心室肥厚的研究进展  

Research progress on prevention and treatment of hypertensive left ventricular hypertrophy by traditional Chinese medicine

作　　者：张金波 孔雪 韩雪玲 戴晶 邹冲[1] ZHANG Jinbo;KONG Xue;HAN Xueling;DAI Jing;ZOU Chong(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210000,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210000

出　　处：《上海中医药杂志》2023年第1期96-99,104,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：江苏省中医药管理局资助项目(JD2019SZ01);江苏省人力资源和社会保障厅六大人才高峰项目(WSN-091);江苏省卫健委老年健康科研项目(LK2021003)。

摘　　要：综述中药改善高血压左心室肥厚(LVH)的研究进展。研究发现黄芪、丹参、天麻等中药具有心脏保护作用,可改善LVH相关指标,降压药物结合中药辨证治疗可进一步提升LVH的逆转率,改善其预后,其作用机制多与调节细胞因子、抑制肾素-血管紧张素-醛固酮系统、改善氧化应激、抑制细胞信号转导通路等相关。The research progress on traditional Chinese medicine(TCM)in preventing and treating hypertensive left ventricular hypertrophy(LVH)has been reviewed.Studies have found that Astragali Radix,Salviae Miltiorrhizae Radix Et Rhizoma,Gastrodiae Rhizoma etc.have cardiac protective effects and can improve LVH related indicators.Antihypertensive drugs combined with TCM syndrome differentiation can further improve the reversal rate of LVH and its prognosis,and the mechanism is mostly related to the regulation of cytokines,inhibition of Renin-Angiotensin-Aldosterone System,improvement of oxidative stress and inhibition of cell signal transduction pathway.

关 键 词：高血压 左心室肥厚 作用机制 中药 研究进展 

分 类 号：R259[医药卫生—中西医结合]