基于“微生物-脑-肠轴”探析中医治疗阿尔茨海默病的思路  

Traditional Chinese medicine treatment for Alzheimer’s disease based on the microbiota-brain-gut axis

作　　者：韩欢 王康锋[2] 侯翰如 刘长宁 李明襄 张立娟[2] HAN Huan;WANG Kangfeng;HOU Hanru;LIU Changning;LI Mingxiang;ZHANG Lijuan(Shandong University of Traditional Chinese Medicine,Ji’nan,Shandong 250014,China;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji’nan,Shandong 250014,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院,山东济南250014

出　　处：《上海中医药杂志》2023年第3期1-5,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81303028);山东省科技发展计划项目(2014GSF119038);山东省中医药科技发展计划项目(2017-040,2019-0107,2019-0094);济南市科技创新发展计划项目(202019027,202134007);山东中医药大学附属医院首批青年科研创新团队项目(2021)。

摘　　要：神经系统和胃肠系统在生理、病理上都有着紧密的联系,脑-肠轴学说的提出进一步证实了大脑与胃肠系统之间紧密相关。越来越多的研究表明肠道微生物可通过作用于脑-肠轴影响阿尔茨海默病的发生和发展进程。以中医理论为基础,以“微生物-脑-肠轴”作为切入点,提出从肠治脑的方法,探讨中医(中药、针灸)治疗阿尔茨海默病的思路,以期为中医药治疗本病提供参考依据。The nervous system and the gastrointestinal system are closely connected physiologically and pathologically.The proposed theory of braingut axis further confirms the strong correlation between the brain and the gastrointestinal system.An increasing number of studies has indicated that gut microbiota can influence the development and progression of Alzheimer’s disease by acting on the brain-gut axis.Based on the theory of traditional Chinese medicine(TCM)and the microbiota-brain-gut axis,we propose the approach of treating the brain from the intestine,and discuss the strategy of applying TCM(including traditional Chinese herbal medicine,acupuncture and moxibustion)to the treatment of Alzheimer’s disease in order to provide reference for clinical TCM treatment.

关 键 词：阿尔茨海默病 痴呆 微生物-脑-肠轴 肠道菌群 中药 针灸 

分 类 号：R277.7[医药卫生—中医学]