分析IUI助孕周期中精子超快速前向运动百分比对精子回收率及临床结局的影响  

To Analyze the Effect of Percentage of Sperm with Super Fast Forward Motility on Sperm Recovery and Clinical Outcomes During IUI Pregnancy Cycle

作　　者：张国忠 胡艳梅[1] 伍学一 张玲 张曦予 Zhang Guozhong;Hu Yanmei;Wu Xueyi(Reproductive Medicine Center,Panzhihua City Maternal and Child Health Hospital,Panzhihua,Sichuan 617000,China)

机构地区：[1]攀枝花市妇幼保健院生殖医学中心,四川攀枝花617000

出　　处：《四川医学》2023年第3期257-261,共5页Sichuan Medical Journal

基　　金：四川省医学青年创新科研课题计划(编号:Q20011)。

摘　　要：目的 探讨精子超快速前向运动百分比(SPR)在不孕不育夫妇接受宫腔内人工授精(IUI)助孕治疗过程中的临床指导意义。方法 回顾性分析2019年1月至2022年8月在我院生殖医学中心行IUI的患者162例,共237个周期患者的临床资料,根据术前精液常规分析指标SPR分为三组,分别为0≤SPR<10%(A组)、10%≤SPR<15%(B组)、15%≤SPR(C组)。分析各组的精液常规分析参数,以及接受IUI助孕治疗时优化前后的精液参数、回收率和临床结局。结果 (1)禁欲天数、精子活率和精子总活力等3个精液参数与SPR具有正相关(P<0.05),液化时间与SPR具有负相关(P<0.05)。(2)在IUI治疗周期中,优化处理前后的精液浓度和精子活率与SPR具有显著正相关性(P<0.05),但精子回收率与SPR无相关性(P>0.05);临床妊娠率与SPR也无相关性(P>0.05)。结论 不孕不育夫妇接受IUI助孕治疗时,SPR的高低对精子回收率没有显著影响,SPR也不能作为接受IUI助孕治疗患者的临床结局的直接预测因素,SPR的临床价值还需进一步探索。Objective To explore the clinical significance of the percentage of sperm with super fast forward motility in infertile couples undergoing intrauterine insemination for pregnancy.Methods The clinical data of 162 patients with 237 cycles who underwent IUI in Reproductive Medicine Center of our hospital from January 2019 to August 2022 were retrospectively analyzed.According to the preoperative semen routine analysis index-SPR,the patients were divided into three groups.They were 0≤SPR<10%(group A),10%≤SPR<15%(group B)and 15%≤SPR(group C),respectively.The parameters of routine semen analysis,the semen parameters,recovery rate and clinical outcome before and after optimization of IUI treatment were analyzed.Results①Three semen parameters including abstinence days,sperm motility and total sperm motility were positively correlated with SPR(P<0.05),while liquefaction time was negatively correlated with SPR(P<0.05).②In the IUI treatment cycle,sperm concentration and sperm motility were positively correlated with SPR before and after optimized treatment(P<0.05),but sperm recovery was not correlated with SPR(P>0.05).There was no correlation between clinical pregnancy rate and SPR(P>0.05).Conclusion The level of SPR has no significant effect on sperm recovery in infertile couples receiving IUI-assisted pregnancy treatment.SPR cannot be used as a direct predictor of clinical outcome in infertile couples receiving IUI-assisted pregnancy treatment.The clinical value of SPR needs to be further explored.

关 键 词：宫腔内人工授精 精子超快速前向运动百分比 回收率 临床结局 

分 类 号：R711.6[医药卫生—妇产科学]