血清低氧诱导因子1α和促红细胞生成素水平与老年慢性肾脏病患者发生贫血的关系  

Relation of serum hypoxia inducible factor 1αand erythropoietin levels with the occurrence of anemia in elderly patients with chronic kidney disease

作　　者：赵芳 赵青 游爱萍 ZHAO Fang;ZHAO Qing;YOU Aiping(Department of Nephrology,Hebei Provincial Eighth People′s Hospital,Shijiazhuang 050000,Hebei,China;Department of Traditional Chinese Medicine,Shijiazhuang Puji Hospital of Integrated Traditional Chinese and Western Medicine,Shijiazhuang 050011,Hebei,China)

机构地区：[1]河北省第八人民医院肾内科,河北省石家庄市050000 [2]石家庄普济中西医结合医院中医科,河北省石家庄市050011

出　　处：《广西医学》2023年第5期523-526,共4页Guangxi Medical Journal

基　　金：河北省医学科学研究课题计划项目(20211709)。

摘　　要：目的探讨血清低氧诱导因子1α(HIF-1α)、促红细胞生成素(EPO)水平与老年慢性肾脏病患者发生贫血的关系。方法选取200例老年慢性肾脏病患者,根据有无贫血将其分为贫血组(120例)和无贫血组(80例)。比较两组患者的一般临床指标及血清HIF-1α、EPO水平。分析贫血组患者血清HIF-1α和EPO水平与血红蛋白、血清铁蛋白水平的相关性。采用Logistic回归模型分析老年慢性肾脏病患者发生贫血的影响因素。结果贫血组血清肌酐、尿素氮、尿酸、HIF-1α水平高于无贫血组,血清铁蛋白和EPO水平、血红蛋白水平、估算肾小球滤过率低于无贫血组(均P<0.05)。贫血组患者血清HIF-1α水平与血清铁蛋白水平、血红蛋白水平均呈负相关(均P<0.05);血清EPO水平与血清铁蛋白水平、血红蛋白水平均呈正相关(均P<0.05)。Logistic回归分析结果显示,血清HIF-1α水平是老年慢性肾脏病患者发生贫血的独立危险因素,血清EPO水平是保护因素(均P<0.05)。结论合并贫血的老年慢性肾脏病患者血清HIF-1α水平升高,血清EPO水平降低,HIF-1α和EPO可能共同参与老年慢性肾脏病患者贫血的发生。Objective To explore the relation of serum hypoxia inducible factor 1α(HIF-1α),erythropoietin(EPO)levels with the occurrence of anemia in elderly patients with chronic kidney disease.Methods A total of 200 elderly patients with chronic kidney disease were selected,and they were assigned to anemia group(120 cases)or non-anemia group(80 cases)according to the presence of anemia.The general clinical indices and the levels of serum HIF-1αand EPO of patients were compared between the two groups.The correlation of serum HIF-1αand EPO levels with hemoglobin and serum ferritin levels of patients in the anemia group was analyzed.The influencing factors for the occurrence of anemia in elderly patients with chronic kidney disease were analyzed by employing Logistic regression model.Results The anemia group exhibited higher levels of serum creatinine,urea nitrogen,uric acid,HIF-1α,and lower levels of serum ferritin,EPO,and hemoglobin,as well as a lower estimated glomerular filtration rate as compared with the non-anemia group(all P<0.05).Serum HIF-1αlevel negatively correlated with serum ferritin and hemoglobin levels(all P<0.05);furthermore,serum EPO level positively correlated with serum ferritin and hemoglobin levels(all P<0.05).The results of Logistic regression analysis revealed that serum HIF-1αlevel was the independent risk factor for the occurrence of anemia in elderly patients with chronic kidney disease,and serum EPO level was the protective factor(all P<0.05).Conclusion Serum HIF-1αlevel is elevated and serum EPO level is decreased in elderly patients with chronic kidney disease and concomitant anemia.HIF-1αand EPO may be jointly involved in the occurrence of anemia in elderly patients with chronic kidney disease.

关 键 词：慢性肾脏病 贫血 老年人 低氧诱导因子1Α 促红细胞生成素 

分 类 号：R692.3[医药卫生—泌尿科学] R[医药卫生—外科学]